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Dynamic Molecular Biochemistry Lab
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A lab that explores the molecular basis of aging through translational stalling.
AboutAbout the lab
Unraveling the dynamic process of translation with cutting-edge technologies
The Dynamic Molecular Biochemistry Lab focuses on translation, the endpoint of the central dogma, and studies the dynamic process by which nascent chains produced by translation mature into functional proteins.
The lab also explores how giant molecular complexes such as the ribosome are assembled with precision inside the cell.
Focusing on quality control mechanisms, the lab investigates how translation becomes more prone to stalling with aging, leading to the accumulation of abnormal proteins.
The lab combines multi-omics, in vitro reconstitution systems, high-speed AFM, cryo-EM, and other analyses in its research.
Key terms
- Central dogma
- The flow of genetic information until it becomes protein. Translation is its endpoint.
- Proteostasis
- Protein homeostasis. Maintaining it in the body is a survival strategy fundamental to life activities.
- Multi-omics
- An approach that integrates RNA-seq, Ribo-seq, and proteome analysis to capture events inside the cell from a bird's-eye view.
NewsLab news
The lab was launched
A paper by Assistant Professor Tomomatsu and colleagues was published in Journal of Biochemistry
A paper by Assistant Professor Tomomatsu and colleagues was published in The EMBO Journal
ResearchResearch themes
The lab uses cutting-edge analytical technologies to unravel the dynamic process by which nascent chains produced by translation mature into functional proteins. Its main subjects are how giant molecular complexes are assembled, and translational stalling and failures of quality control that accompany aging.
*Illustrative imagePrecise assembly of giant molecular complexes
The lab explores how giant molecular complexes such as the ribosome and the proteasome are assembled with precision in the crowded environment of the cell. It also focuses on the individuality of each complex, including the possibility that slight differences in their components change their function.
*Illustrative imageAging, translational stalling, and failure of quality control
As an issue related to maintaining protein homeostasis (proteostasis), the lab focuses on the increase in ribosome stalling and the accumulation of abnormal proteins that accompany aging. Focusing on the dynamics of a quality control factor it discovered independently, the lab aims to clarify the whole picture, from the sources of stalling to accumulation and aggregation.
*Illustrative imageFrom multi-omics to single-molecule analysis
Using multi-omics that integrates RNA-seq, Ribo-seq, and proteome analysis, the lab captures events inside the cell from a bird's-eye view. It analyzes samples prepared with in vitro reconstitution systems by high-speed AFM and cryo-EM, and verifies the dynamics and structure of giant complexes at the single-molecule level.
MembersFaculty
The members of the Dynamic Molecular Biochemistry Lab consist of faculty, undergraduate students, and a secretary.As of 2026
- ProfessorYoshitaka Matsuo
- Assistant ProfessorShota Tomomatsu
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “P. urativorans 70S ribosome with Balon and RaiA” Helena-Bueno, K., Rybak, M.Y., Gagnon, M.G., Hill, C.H., Melnikov, S.V. / CC0 (cropped)
- Precise assembly of giant molecular complexes: “Multiple Ribosomes Translation Protein Synthesis” Christinelmiller / CC BY-SA 4.0 (cropped)
- Aging, translational stalling, and failure of quality control: “Ribosome mRNA translation ta” G.Kiruthikan / CC BY-SA 3.0 (cropped)
- From multi-omics to single-molecule analysis: “Protein pattern analyzer” 作者不詳 / Public domain (cropped)
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