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Chromosome Structure and Function Lab
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The lab explores the unknown functions of chromatin and chromosomes.
AboutAbout the lab
Exploring the unknown functions of chromatin and chromosomes
The Chromosome Structure and Function Lab studies at the molecular level how genetic information is packaged in the nucleus, inherited, and regulated in its expression.
DNA, the blueprint that builds the body, is a long molecule that reaches about 2 meters in humans, yet it fits inside a nucleus about 10 µm in diameter.
This molecule is accurately passed on to tens of trillions of cells, and its expression is tightly regulated as the body develops.
The lab's research results page introduces papers on the regulation of stem cell differentiation and the repair of broken DNA.
Key terms
- Chromatin
- The state in which DNA is folded together with proteins and other components inside the cell nucleus
- Expression regulation
- The adjustment of which genes are activated, and when, based on genetic information
- Stem cells
- Source cells with the ability to turn into many different types of cells
NewsLab news
A paper was published in Cell Reports, revealing a regulatory mechanism that prevents stem cells from running out of control
A doctoral student won an MBSJ Poster Award at the Annual Meeting of the Molecular Biology Society of Japan
ResearchResearch themes
The lab sets out to explore the unknown functions of chromatin and chromosomes. It aims to understand at the molecular level how genetic information is packaged in the nucleus, passed on to the next generation, and regulated in its expression.
View More ↗MembersFaculty
The Chromosome Structure and Function Lab consists of faculty, doctoral, master's, and undergraduate students, administrative assistants, and technical assistants.As of 2026
- ProfessorChikashi Obuse
- Associate ProfessorKoji Nagao
- Assistant ProfessorTakamasa Ito
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human karyotype (248 27) Human karyotype” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
- Related lab (分子発生学研究室): “Confocal Microscope” Mark from Edinburgh, United Kingdom / CC BY-SA 2.0 (cropped)
- Related lab (ゲノムー染色体機能学研究室): “Independent assortment” Christinelmiller / CC BY-SA 4.0 (cropped)
- Related lab (学際グループ（核機能学分野）
): “Yeast cells in wet mount of culture” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped) - Related lab (分子遺伝学研究室): “Human karyotype (259 30) Karyotype Human 47,XXY (Klinefelter)” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
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