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Cellular Life Science Lab
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A lab that studies the dynamics of mitochondria, including how they fuse and divide.
AboutAbout the lab
Studying mitochondrial dynamics
The Cellular Life Science Lab studies the "dynamics" of mitochondria, which change shape through fusion and fission.
The lab approaches the topic from two sides: the molecular mechanisms that change membrane shape, and the significance of these processes, including their roles in a healthy body and their effects in disease.
The lab combines cell culture experiments, biochemical experiments using isolated mitochondria and purified proteins, and experiments involving mouse genes.
On the lab's website, it is introduced as the "Ishihara Lab."
Key terms
- Mitochondria
- Organelles that produce most of the cell's energy through oxygen respiration. They also play a central role in controlling cell death.
- Organelle
- A membrane-bound structure inside a cell. Mitochondria are one example.
- GTPase
- A GTP-hydrolyzing enzyme. Several GTPases are thought to be required for mitochondrial fusion and fission.
NewsLab news
View More ↗ResearchResearch themes
Mitochondria are elongated organelles with a double-membrane structure, and in living cells they constantly change shape by repeatedly undergoing fusion and fission. The lab seeks to clarify the mechanisms and physiological significance of these processes using the methods of cell biology, biochemistry, and mouse genetics.
*Illustrative imageMolecular mechanisms of fusion and fission
Several GTPases are required for mitochondrial fusion and fission, but their functions are still poorly understood. By identifying and analyzing novel factors, using biochemical methods in addition to cell biology, the lab aims to clarify the molecular basis that controls membrane structure.
*Illustrative imageThe significance of mitochondrial shape changes
Mitochondria change shape dramatically during cellular responses and tissue differentiation, yet why they undergo fusion and fission remains largely unknown. The lab investigates their physiological functions using cell culture and mouse molecular genetics.
MembersFaculty
The members of the Cellular Life Science Lab consist of faculty, project researchers, visiting professors, associate professors, and researchers, doctoral, master's, and undergraduate students, short-term international students, administrative assistants, and technical assistants.
- ProfessorNaotada Ishihara
- Assistant ProfessorEmi Ogasawara
- Assistant ProfessorKeisuke Takeda
- Project Assistant ProfessorYuichi Matsushima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mitochondria in living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
- Molecular mechanisms of fusion and fission: “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
- The significance of mitochondrial shape changes: “Mitochondria cell division” Pradana Aumars / CC0 (cropped)
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