Labs in Nagoya University

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The lab approaches psychiatric disorders through the brain mechanisms that govern emotion.

The Systems Neuropharmacology Lab conducts research aimed at elucidating the complex neural mechanisms that govern emotional behavior and contributing to progress in psychiatric disorder research, which has reached an impasse. The lab studies brain function by combining cutting-edge technologies such as whole-brain imaging, calcium imaging, and optogenetic and chemogenetic methods. The lab places importance on respecting the autonomy of students and young researchers, so that they can enjoy their research. On the lab's website, it is presented under the name "Kasai Lab."

#Emotion #Psychiatric disorders #Claustrum

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The lab investigates the pathology of endocrine and metabolic disorders using models such as glucagon gene-modified models.

The Endocrinology and Metabolism Lab belongs to the Division of Biological Adaptation and Protection at the Research Institute of Environmental Medicine. The lab conducts research in endocrine metabolism and molecular biology using models in which the glucagon gene has been modified. Its current research topics also include the pathophysiology of malignant tumors of the endocrine system, the mechanisms by which endoderm-derived cells differentiate, and the pathophysiology of hereditary endocrine diseases. Its research keywords include endocrinology, pancreatic islets, the thyroid, diabetes, cell differentiation, and transcriptional regulation.

#Endocrinology #Diabetes #Pancreatic islets

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A lab investigating the relationship between genome instability and disease.

The Development and Genetics Lab conducts research under the keyword "genome instability and disease." Genome instability disorders are intractable diseases that occur when pathways that repair or recognize DNA damage do not function normally. The lab searches for the genes that cause these diseases by combining cell-based experiments that examine DNA repair function with next-generation genome analysis, and links the results to diagnosis. At the bottom of the lab's website, the names of the Development and Genetics Division of the Research Institute of Environmental Medicine, the Department of Human Genetics and Molecular Genetics of the Graduate School of Medicine, and the Gene Analysis Division of the Genome Medicine Center at the University Hospital are listed together.

#Genome instability disorders #DNA repair #Omics analysis

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A lab investigating the mechanisms of ALS and Alzheimer's disease through glial cells.

The Pathological Neuroscience Lab aims to clarify the pathology of amyotrophic lateral sclerosis (ALS), which damages motor neurons, and Alzheimer's disease, a leading cause of dementia, and to develop new treatments. The lab creates and analyzes model mice and cultured cells carrying disease-related genes, and applies the results to understanding the mechanisms of sporadic, non-hereditary forms of these diseases. It has shown that abnormalities in the glial cells surrounding neurons accelerate the progression of neurodegeneration in ALS. The lab is recruiting graduate students (master's and doctoral programs), and undergraduate students and research students can also take part in its research.

#Amyotrophic lateral sclerosis #Alzheimer's disease #Glial cells

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A lab investigating the mechanisms of fibrosis, in which tissue becomes stiff.

The Disease Regulation Lab studies myofibroblasts, which are involved in fibrosis, the hardening of tissue. Fibrosis occurs when myofibroblasts overproduce and accumulate extracellular matrix such as collagen, and it is thought to be involved in chronic diseases and the progression of cancer. Because there is no definitive treatment, the lab investigates the molecules that promote fibrosis and the properties of myofibroblasts, aiming to lay the foundation for developing new therapies. Using fibrosis of the heart and liver as examples, the lab conducts its studies with mice and cells.

#Fibrosis #Myofibroblasts #Collagen

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The lab studies genome dynamics, focusing on how cells respond to DNA damage.

The Genome Dynamics Regulation Lab studies how cells respond when DNA is damaged. DNA is easily damaged. Abnormalities in the mechanisms that respond to damage make the genome unstable, which is thought to cause diseases such as cancer and premature aging. Centering on the mechanism that replicates DNA past lesions, the lab investigates how the genome is kept stable. On the lab's website, it is presented under the name "Masutani Lab."

#DNA damage tolerance #Translesion DNA synthesis #Genome stability

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疾患ゲノム解析セクション (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.

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疾患モデル解析セクション (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.

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The lab explores the neural circuits in the brain that determine the timing of sleep and body temperature.

The Young Researcher Incubation Section Lab studies how the brain decides when animals sleep, when they eat, and when they reproduce. Starting from the suprachiasmatic nucleus, the center of the brain's circadian clock, the lab investigates the neural circuits that control sleep, body temperature, and metabolism at the right times. Combining techniques such as optogenetics and optical imaging, it studies a wide range of animals, from Hydra to mice. On the lab's website, it is presented under the name "Ono Research Unit."

#Circadian clock #Sleep #Neural circuits

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An industry-academia joint lab where Nagoya University and Raqualia Pharma work to create new drugs.

The Raqualia Pharma Industry-Academia Collaborative Lab is a joint research lab run by Nagoya University and Raqualia Pharma Inc. Through industry-academia collaboration, its mission is to create new drugs from the Chubu region. It consists of the Pharmacological Efficacy Analysis Division, the Translational Research Division, and the New Drug Creation Science Division, and is housed within the Research Institute of Environmental Medicine. Each division also functions as a research team with the Graduate School of Medicine and the Graduate School of Pharmaceutical Sciences, and the lab describes itself as the link that ties these three units together in advancing drug discovery research.

#Drug discovery #Industry-academia collaboration #Drug efficacy evaluation