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12 labs · 0 student voices
Faculties at Nagoya University ›
Sayaka Takemoto-Kimura-Kimura, Professor
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The Neural Systems Lab uses calcium signaling characteristic of neurons as a clue to study the mechanisms by which the brain forms and changes, as well as the causes and pathology of psychiatric and neurological disorders that arise when these mechanisms break down. The lab conducts basic research mainly on mice as model animals, using methods such as molecular and cell biology, calcium imaging including in vivo imaging, histology, behavioral analysis, and circuit manipulation. Its research targets range from cultured neurons to phenomena in the brain. The lab's website introduces it under the name "Takemoto-Kimura Lab."
Takayoshi Sugami, Professor
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The Molecular Metabolic Medicine Lab studies the mechanisms of chronic inflammation involved in lifestyle-related diseases such as obesity and diabetes. Focusing on immunometabolism, the interface between nutrition/metabolism and inflammation/immunity, the lab positions itself as a bridge between basic and clinical research and aims to conduct research that leads to clinical applications. The lab interacts with researchers from diverse backgrounds both inside and outside the lab, and also engages in medical-engineering collaboration with researchers from other fields. The lab also serves as a cooperating department (Immunometabolism) of the Graduate School of Medicine, Nagoya University.
Atsushi Kasai, Professor
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The Systems Neuropharmacology Lab conducts research aimed at elucidating the complex neural mechanisms that govern emotional behavior and contributing to progress in psychiatric disorder research, which has reached an impasse. The lab studies brain function by combining cutting-edge technologies such as whole-brain imaging, calcium imaging, and optogenetic and chemogenetic methods. The lab places importance on respecting the autonomy of students and young researchers, so that they can enjoy their research. On the lab's website, it is presented under the name "Kasai Lab."
Yoshitaka Hayashi, Professor
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The Endocrinology and Metabolism Lab belongs to the Division of Biological Adaptation and Protection at the Research Institute of Environmental Medicine. The lab conducts research in endocrine metabolism and molecular biology using models in which the glucagon gene has been modified. Its current research topics also include the pathophysiology of malignant tumors of the endocrine system, the mechanisms by which endoderm-derived cells differentiate, and the pathophysiology of hereditary endocrine diseases. Its research keywords include endocrinology, pancreatic islets, the thyroid, diabetes, cell differentiation, and transcriptional regulation.
Tomoo Ogi, Professor
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The Development and Genetics Lab conducts research under the keyword "genome instability and disease." Genome instability disorders are intractable diseases that occur when pathways that repair or recognize DNA damage do not function normally. The lab searches for the genes that cause these diseases by combining cell-based experiments that examine DNA repair function with next-generation genome analysis, and links the results to diagnosis. At the bottom of the lab's website, the names of the Development and Genetics Division of the Research Institute of Environmental Medicine, the Department of Human Genetics and Molecular Genetics of the Graduate School of Medicine, and the Gene Analysis Division of the Genome Medicine Center at the University Hospital are listed together.
Koji Yamanaka, Professor
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The Pathological Neuroscience Lab aims to clarify the pathology of amyotrophic lateral sclerosis (ALS), which damages motor neurons, and Alzheimer's disease, a leading cause of dementia, and to develop new treatments. The lab creates and analyzes model mice and cultured cells carrying disease-related genes, and applies the results to understanding the mechanisms of sporadic, non-hereditary forms of these diseases. It has shown that abnormalities in the glial cells surrounding neurons accelerate the progression of neurodegeneration in ALS. The lab is recruiting graduate students (master's and doctoral programs), and undergraduate students and research students can also take part in its research.
Michio Nakaya, Professor
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The Disease Regulation Lab studies myofibroblasts, which are involved in fibrosis, the hardening of tissue. Fibrosis occurs when myofibroblasts overproduce and accumulate extracellular matrix such as collagen, and it is thought to be involved in chronic diseases and the progression of cancer. Because there is no definitive treatment, the lab investigates the molecules that promote fibrosis and the properties of myofibroblasts, aiming to lay the foundation for developing new therapies. Using fibrosis of the heart and liver as examples, the lab conducts its studies with mice and cells.
Chikahide Masutani, Professor
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The Genome Dynamics Regulation Lab studies how cells respond when DNA is damaged. DNA is easily damaged. Abnormalities in the mechanisms that respond to damage make the genome unstable, which is thought to cause diseases such as cancer and premature aging. Centering on the mechanism that replicates DNA past lesions, the lab investigates how the genome is kept stable. On the lab's website, it is presented under the name "Masutani Lab."
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