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Genome Dynamics Regulation Lab
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The lab studies genome dynamics, focusing on how cells respond to DNA damage.
AboutAbout the lab
Uncovering how the genome is kept stable
The Genome Dynamics Regulation Lab studies how cells respond when DNA is damaged.
DNA is easily damaged.
Abnormalities in the mechanisms that respond to damage make the genome unstable, which is thought to cause diseases such as cancer and premature aging.
Centering on the mechanism that replicates DNA past lesions, the lab investigates how the genome is kept stable.
On the lab's website, it is presented under the name "Masutani Lab."
Key terms
- DNA damage tolerance
- A cellular mechanism that allows replication to proceed despite DNA lesions. Translesion DNA synthesis is one example
- Translesion DNA synthesis
- A mechanism that replicates DNA by using damaged DNA as a template and bypassing the lesion. Often abbreviated TLS
- Polη
- A DNA polymerase (polymerase eta) that replicates DNA past lesions, using DNA damaged by ultraviolet light as a template
- Xeroderma pigmentosum
- A genetic disease characterized by high sensitivity to ultraviolet light and a high incidence of cancer
NewsLab news
View More ↗ResearchResearch themes
DNA is easily damaged by agents such as ultraviolet light, and abnormalities in the mechanisms that respond to damage are thought to destabilize the genome. The lab studies how cells respond to DNA damage, aiming to clarify the molecular basis of carcinogenesis and aging.
*Illustrative imageMechanism and Regulation of Translesion DNA Synthesis
Polη, the enzyme responsible for xeroderma pigmentosum variant, replicates DNA past lesions caused by ultraviolet light. The lab studies how it is regulated, focusing on protein-protein interactions and post-translational modifications.
*Illustrative imageDNA Damage Tolerance in Human Cells
In human cells, the mechanisms of pathways other than translesion DNA synthesis are still poorly understood. Using cell biology and biochemical methods, the lab studies responses to UV damage as well as to damage caused by illudin S, a mushroom toxin, and to abasic sites.
*Illustrative imageDrug Discovery Targeting Damage Tolerance
Focusing on the relationship between cancer cell proliferation and DNA damage tolerance, the lab conducts its research with the development of anticancer drugs that target this mechanism in mind. It is always conscious of applying the results of basic research to drug discovery.
MembersFaculty
Members of the Genome Dynamics Regulation Lab include faculty, master's and undergraduate students, technicians, and administrative assistants.As of 2026
- ProfessorChikahide Masutani
- Associate ProfessorYuji Masuda
- Assistant ProfessorRie Kanao
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Agarose gel electrophoresis DNA” Microrao / CC BY-SA 4.0 (cropped)
- Mechanism and Regulation of Translesion DNA Synthesis: “5D46 crystal structure of TdT with a DNA substrate” Fravadona / CC0 (cropped)
- DNA Damage Tolerance in Human Cells: “Culture flasks cabinet in MPI-CBG 01” Matylda Sęk / CC BY-SA 3.0 (cropped)
- Drug Discovery Targeting Damage Tolerance: “Pharmacy, Medicine Store” ManzoorRph / CC BY-SA 4.0 (cropped)
- Related lab (内分泌代謝分野): “(20250417) Blood glucose meter 08” Roy Zuo / CC BY-SA 4.0 (cropped)
- Related lab (発生・
遺伝分野): “DNA Double Helix Model - Human Evolution Gallery - Indian Museum - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped) - Related lab (疾患制御学分野): “Collagen (triple helix protein with schematic ribbons)” Eric Hahn / CC BY-SA 4.0 (cropped)
- Related lab (ラクオリア創薬産学協同研究所): “D415-104 INTERIOR OF THE RESEARCH LABORATORY AT THE ABIC PHARMACEUTICS FACTORY IN RAMAT GAN” MILNER MOSHE משה מילנר / Public domain (cropped)
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