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Disease Regulation Lab
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A lab investigating the mechanisms of fibrosis, in which tissue becomes stiff.
AboutAbout the lab
Understanding fibrosis-causing cells at the molecular level.
The Disease Regulation Lab studies myofibroblasts, which are involved in fibrosis, the hardening of tissue.
Fibrosis occurs when myofibroblasts overproduce and accumulate extracellular matrix such as collagen, and it is thought to be involved in chronic diseases and the progression of cancer.
Because there is no definitive treatment, the lab investigates the molecules that promote fibrosis and the properties of myofibroblasts, aiming to lay the foundation for developing new therapies.
Using fibrosis of the heart and liver as examples, the lab conducts its studies with mice and cells.
Key terms
- Fibrosis
- A condition in which proteins such as collagen are produced excessively in tissue and accumulate. The tissue becomes stiff
- Myofibroblast
- A cell that changes from a fibroblast in response to inflammation and produces collagen and other components
- Extracellular matrix
- Proteins such as collagen that are produced outside cells
ResearchResearch themes
Fibrosis occurs when myofibroblasts produce excessive amounts of collagen and other components. The lab examines the molecules that promote fibrosis and the properties of myofibroblasts that produce large amounts of collagen, aiming to lay the foundation for new treatments.
*Illustrative imageSearching for molecules that promote fibrosis
The lab studies PRELP, a protein whose expression increases in fibrosis of the heart and liver. It has been found to appear specifically in myofibroblasts with chondrocyte-like properties and to promote collagen production, and it is considered a possible therapeutic target.
*Illustrative imageMyofibroblast subpopulations and their fate
The lab has found that the expression of a certain protein determines a subpopulation of myofibroblasts that produce large amounts of collagen. By analyzing the fate of this subpopulation, it aims to lay the foundation for new fibrosis treatments.
*Illustrative imageGene delivery into myofibroblasts
The lab developed a method that uses a retrovirus to deliver a gene of interest into myofibroblasts in the mouse heart immediately after myocardial infarction. Conventional methods involved many steps and were time-consuming and costly.
MembersFaculty
- ProfessorMichio Nakaya
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Collagen (triple helix protein with schematic ribbons)” Eric Hahn / CC BY-SA 4.0 (cropped)
- Searching for molecules that promote fibrosis: “Bridging fibrosis in rat liver” Durgesh1104 / CC BY-SA 4.0 (cropped)
- Myofibroblast subpopulations and their fate: “Indian Muntjac fibroblast cells ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Gene delivery into myofibroblasts: “DNA Double Helix by NHGRI” National Human Genome Research Institute / Public domain (cropped)
- Related lab (Endocrinology and Metabolism Lab): “(20250417) Blood glucose meter 08” Roy Zuo / CC BY-SA 4.0 (cropped)
- Related lab (Genome Dynamics Regulation Lab): “Agarose gel electrophoresis DNA” Microrao / CC BY-SA 4.0 (cropped)
- Related lab (Development and Genetics Lab): “DNA Double Helix Model - Human Evolution Gallery - Indian Museum - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Molecular Metabolic Medicine Lab): “Pipette de laboratoire sur fond blanc au Bénin 02” Adoscam / CC BY-SA 4.0 (cropped)
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