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115 labs · 0 student voices
Faculties at University of Tsukuba ›
Satoru Takahashi, Professor
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The Anatomy and Embryology Lab uses a variety of genetically modified mice to study the molecular mechanisms underlying life phenomena and the mechanisms by which diseases arise. The lab focuses on the Maf family of transcription factors and on the functions of macrophages, a type of immune cell, and investigates the mechanisms of development and differentiation, metabolism, and disease onset. It also works on the functions of glycans and on changes in gene expression in mice raised in space. On the lab's website, it is presented under the name "Takahashi Lab."
Yosuke Takei, Professor
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The Anatomy and Neuroscience Lab studies the mechanisms of psychiatric disorders such as schizophrenia and autism spectrum disorder. The lab investigates everything from the small scale of molecules to the large scale of brain formation, aiming to lead to treatments and preventive measures. It focuses in particular on the intracellular transport system that carries materials inside neurons, and on the relationship between the immune system and the nervous system. On the lab's website, the lab is introduced under the name "Takei Lab."
Daisuke Matsubara, Professor
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The Diagnostic Pathology Lab conducts research directly linked to clinical practice and studies molecules involved in the development and progression of cancer. With a pathologist's eye, the lab carefully observes cancer heterogeneity, background lesions, minute lesions, early lesions, and the process of progression. The lab proceeds with its analyses by comparing them against the genetic data of its many cancer cell lines, the tissue morphology of xenograft tumors, and drug sensitivity. In addition to research and clinical practice, the diagnostic pathology group engages in various activities, including the Tsukuba Human Tissue Diagnosis Center, which supports pathological diagnosis in the region.
Genta Nagae, Professor
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The Molecular Pathology Lab clarifies abnormalities in cancer cells at the molecular level, aiming to establish methods to specifically damage cancer cells. The lab focuses on transforming growth factor-β (TGF-β), which is activated in many cancer tissues, and on induction of stemness, in which some cancer cells that have stopped proliferating acquire stem cell properties. Focusing on cancer stem cells that resist treatment as a cause of metastasis and recurrence after therapy, the lab is developing treatments that target the mechanism by which induction of stemness makes cancer stem cells increase rapidly. On the lab's website, the lab is introduced under the name "Experimental Pathology Lab," and the content here is based on descriptions from around 2023.
Hiroshi Yamada, Associate Professor
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The Cognitive and Behavioral Neuroscience Lab conducts neuroscience research using monkeys, aiming to understand how human values arise from the brain. In neuroeconomics, a field that combines neuroscience and microeconomics, the lab studies how the brain works when judging whether things are good or bad. Humans and macaque monkeys, a model animal, perform cognitive behavioral tasks, and the lab examines how the brain makes value judgments depending on the degree of thirst or hunger. By manipulating brain activity and examining its effect on judgment, the lab aims to advance the understanding of depression.
Tadachika Koganezawa, Associate Professor
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The Neurophysiology Lab studies the regulation of blood circulation and respiratory movements in order to clarify how the brain maintains homeostasis in the body. If the brain's control of blood circulation does not work properly, it can cause serious cardiovascular diseases, so the lab works to clarify how this control actually operates. Using rodent preparations, mainly with electrophysiological methods, the lab examines in detail the brain centers that regulate circulation and breathing. The lab is recruiting graduate students to conduct research together, and also accepts undergraduate students for graduation research.
Takeshi Sakurai, Professor
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The Molecular Behavioral Physiology Lab studies sleep and wakefulness, feeding behavior, the circadian clock, and emotion and affect through the actions of neuropeptides in the brain. Using genetically modified mice, the lab investigates from the molecular and cellular levels while aiming to understand functions at the level of the whole organism. It also works to clarify the functions of neuropeptides such as orexin, and studies neurons that put mice into a hibernation-like state. On the lab's website, it is introduced as the "Sakurai/Hirano Lab," a lab of the International Institute for Integrative Sleep Medicine (WPI-IIIS).
Katsuyasu Sakurai, Associate Professor
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The Adaptive Physiology Lab studies how information about internal mental and physical states, and about external circumstances and stimuli, is processed in the brain. Living organisms adapt, both consciously and unconsciously, to their internal states and to external circumstances and stimuli. For example, food that goes unnoticed when one is full draws more attention and desire when one is hungry. On the lab's website, the lab is introduced under the name "Liu/Sakurai Lab."
Mitsuaki Kashiwagi, Assistant Professor
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The lab of Assistant Professor Mitsuaki Kashiwagi uses mice to study the neural circuits in the brain that generate REM sleep and the mechanisms that regulate them. Mammalian sleep consists of REM sleep and non-REM sleep, and the mechanisms and functions of REM sleep are considered to be less well understood than those of non-REM sleep. Assistant Professor Kashiwagi and colleagues have identified a brainstem neural circuit that plays an extremely important role in inducing REM sleep, and they are advancing their research starting from this circuit. The lab is also trying to clarify how the cerebral cortex becomes active during REM sleep, using manipulation of neural circuits and imaging.
Shun Nakajima, Project Associate Professor
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The Digital Behavioral Science Lab combines cognitive behavioral therapy with generative AI and the latest technologies, aiming to make mental health support easy for everyone to use and to spread it throughout society. The lab conducts research that integrates clinical psychology, medicine, and information science, and its researchers include people qualified as clinical psychologists, physicians, and nurses. The lab also uses sensing devices that measure gaze, skin potential, and other signals to capture, from multiple angles (multimodally), the mental and physical changes that occur during cognitive behavioral therapy. Graduate students are accepted through the Basic Psychological Science subprogram of the Degree Program in Psychology. The lab does not provide guidance for clinical psychologist training courses.
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