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Anatomy and Embryology Lab
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A lab that uses genetically modified mice to explore the mechanisms of diseases and life phenomena.
AboutAbout the lab
Exploring disease mechanisms with genetically modified mice.
The Anatomy and Embryology Lab uses a variety of genetically modified mice to study the molecular mechanisms underlying life phenomena and the mechanisms by which diseases arise.
The lab focuses on the Maf family of transcription factors and on the functions of macrophages, a type of immune cell, and investigates the mechanisms of development and differentiation, metabolism, and disease onset.
It also works on the functions of glycans and on changes in gene expression in mice raised in space.
On the lab's website, it is presented under the name "Takahashi Lab."
Key terms
- Transcription factor
- A protein that regulates the activity of genes. This lab focuses on the Maf family
- Macrophage
- An immune cell essential for host defense and the maintenance of homeostasis. When its function breaks down, it can also cause various diseases
- Glycan
- A chain of sugars attached to proteins. It is thought to play important roles in many life phenomena (glycan)
NewsLab news
A student received the Young Scientist Poster Presentation Award at ACGG/AGS
A paper by a doctoral student was published in Scientific Reports
A doctoral student received the Student Award (Excellence Prize) at the 12th Annual Meeting of the Japanese Society of Myology
A master's student received the Excellent Presentation Award at the 66th Annual Meeting of the Japanese Teratology Society
Associate Professor Ryo Fujita received the Encouragement Award of the Japan Society for Biomedical Gerontology
ResearchResearch themes
The lab pursues several research themes using a variety of genetically modified mice. Taking the Maf transcription factors, macrophages, glycans, and responses to the space environment as subjects, it investigates the molecular mechanisms underlying life phenomena and the mechanisms of disease onset.
*Illustrative imageMaf transcription factors and mouse diseases
The lab examines abnormalities in mice with modified c-Maf and MafA genes. MafA single-nucleotide mutant mice progress from diabetes to kidney cancer, and c-Maf single-nucleotide mutant mice develop Aymé-Gripp syndrome, a rare disease.
*Illustrative imageThe transcription factor MAFB in macrophages
The lab investigates the role of MAFB, a transcription factor that functions in macrophages, a type of immune cell. It has shown that MAFB is involved in promoting atherosclerosis and in regulating expression of complement C1q, and has recently found that it is also involved in regulating inflammatory lipid mediators in ischemic acute kidney injury and in regulating nerve density in brown adipose tissue in response to cold stimulation.
*Illustrative imageFunctions of glycans in the living body
The lab creates genetically modified mice for glycosyltransferase genes and studies the functions of glycans at the level of the whole organism. Currently, it analyzes conditional knockout mice of a gene essential for the synthesis of mucin-type O-linked glycans, to explore the roles of glycans in each tissue.
*Illustrative imageMouse responses to the space environment
The lab raises mice in space for long periods and comprehensively examines how the space environment changes gene expression in each organ. It states that this can contribute to elucidating the mechanisms of bone loss and muscle atrophy, and the effects of long-term exposure to low-dose radiation.
MembersFaculty
The members of the Takahashi Lab consist of faculty, postdoctoral researchers, part-time researchers, doctoral, master's, and undergraduate students, technical assistants, dispatched staff, technicians, and collaborators.As of 2026
- ProfessorSatoru Takahashi
- Associate ProfessorTakashi Kudo
- Associate ProfessorEiji Warabi
- Associate ProfessorRyo Fujita
- Assistant ProfessorMasaharu Yoshihara
- Assistant ProfessorMitsunori Fujino
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory microcentrifuge tubes and pipette tips 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Maf transcription factors and mouse diseases: “CSIRO ScienceImage 610 PCR Machine in Genetics Laboratory” K. Aken, CSIRO / CC BY 3.0 (cropped)
- The transcription factor MAFB in macrophages: “Effect of immune cells on Tumors” ThatBio / CC0 (cropped)
- Functions of glycans in the living body: “Neu5NH2” glycoform / Public domain (cropped)
- Mouse responses to the space environment: “STS-134 International Space Station after undocking” NASA / Public domain (cropped)
- Related lab (再生幹細胞生物学): “Laboratory Incubator; from a medical laboratory in Abuja, Nigeria” Frankincense Diala / CC0 (cropped)
- Related lab (遺伝子制御学): “Centrifuge tubes ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (分子病理学): “Laminar flow hood 2” TimVickers / Public domain (cropped)
- Related lab (細胞情報制御学): “Confocal microscope AR” Ciphers / CC BY 3.0 (cropped)
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