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Anatomy and Neuroscience Lab
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A lab exploring the mechanisms of psychiatric disorders by focusing on intracellular transport and immunity.
AboutAbout the lab
Approaching psychiatric disorders through intracellular transport and immunity.
The Anatomy and Neuroscience Lab studies the mechanisms of psychiatric disorders such as schizophrenia and autism spectrum disorder.
The lab investigates everything from the small scale of molecules to the large scale of brain formation, aiming to lead to treatments and preventive measures.
It focuses in particular on the intracellular transport system that carries materials inside neurons, and on the relationship between the immune system and the nervous system.
On the lab's website, the lab is introduced under the name "Takei Lab."
Key terms
- Synapse
- A junction where neurons pass signals to each other
- NMDA-type glutamate receptor
- A receptor that works by binding glutamate. It is deeply involved in memory and learning
- Microtubule
- A tubular structure running through the cell. It serves as the track for transporting receptors
- Light scattering measurement
- A measurement method that uses light scattering. It is non-destructive and non-contact, and does not require fluorescent labeling
NewsLab news
Recruiting students and researchers to take part in research on the prenatal environment during pregnancy, psychiatric disorders, and formation of cerebral cortical areas
A student won an Excellent Poster Award at the student session of the Annual Meeting of the Japanese Association of Anatomists
ResearchResearch themes
The lab aims to clarify the molecular mechanisms of the intracellular transport system in neurons and its role in brain function, and to explore how breakdowns in transport lead to the pathogenesis of psychiatric disorders. Based on the fact that activation of the maternal immune response affects the development and function of the fetal brain, the lab also creates animal models of neuropsychiatric disorders and aims to elucidate how immune abnormalities lead to the breakdown of neural function.
*Illustrative imageIntracellular Transport Supporting Synaptic Function
After receptors are produced in places such as the cell body, they are carried through dendrites to the synaptic region. Transport has three stages: transport along microtubules, transfer to actin filaments, and transport along actin filaments. The lab studies how this is regulated and what role it plays in the brain.
*Illustrative imagePreventing Derailment of NMDA Receptor Transport
In collaboration with the lab of Prof. Hirokawa at the University of Tokyo, the lab found that a molecule called MAP1A links NMDA-type glutamate receptors to microtubules while they are being transported, stabilizing them and preventing them from derailing from the track. Mice lacking MAP1A had impaired memory.
*Illustrative imageA Memory-Rewriting Mechanism inside Neurons
The lab found that receptor transport by the kinesin molecular motor KIF17 stops temporarily when KIF17 is degraded in response to neural activity, and then resumes soon afterward within dendrites. Mice in which this mechanism does not work were hardly able to extinguish fear memories.
*Illustrative imageOptical Measurement for Observing Transport in Neurites
To detect the shape of neurons at high resolution and high speed, the lab uses light scattering measurement. It can measure with a time resolution below one millisecond, non-destructively and without contact, and does not require fluorescent labeling.
MembersFaculty
The members of the Anatomy and Neuroscience Lab consist of faculty, faculty in charge of practical training, master's and undergraduate students, technical staff, visiting students, and visiting researchers.As of 2026
- ProfessorYosuke Takei
- Associate ProfessorTetsuya Sasaki
- Assistant ProfessorSuguru Iwata
- Assistant ProfessorMomo Iwata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “McGovern Institute for Brain Research Schwerpunkt” BXu99 / CC BY-SA 4.0 (cropped)
- Intracellular Transport Supporting Synaptic Function: “Rat Arc protein” Yee, Yvonne / CC BY 4.0 (cropped)
- Preventing Derailment of NMDA Receptor Transport: “Microtubules in Primary Mouse Embryonic Fibroblasts” Howard Vindin / CC BY 4.0 (cropped)
- A Memory-Rewriting Mechanism inside Neurons: “GFP Neurons” ManuelSchottdorf / CC BY-SA 4.0 (cropped)
- Optical Measurement for Observing Transport in Neurites: “Laser Optics - Idaho National Laboratory” Idaho National Laboratory / CC BY 2.0 (cropped)
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