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Diagnostic Pathology Lab
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A lab exploring how cancer develops and progresses through the eyes of pathologists.
AboutAbout the lab
Watching cancer's development and progression through a pathologist's eyes.
The Diagnostic Pathology Lab conducts research directly linked to clinical practice and studies molecules involved in the development and progression of cancer.
With a pathologist's eye, the lab carefully observes cancer heterogeneity, background lesions, minute lesions, early lesions, and the process of progression.
The lab proceeds with its analyses by comparing them against the genetic data of its many cancer cell lines, the tissue morphology of xenograft tumors, and drug sensitivity.
In addition to research and clinical practice, the diagnostic pathology group engages in various activities, including the Tsukuba Human Tissue Diagnosis Center, which supports pathological diagnosis in the region.
Key terms
- heterogeneity
- The fact that, even within the same type of cancer, properties differ by location and by cell
- Xenograft tumor
- A tumor created by transplanting cancer cells into an animal. It is used to study tissue morphology and how well drugs work
- EVG staining
- Elastica van Gieson staining. One of the staining methods for pathological specimens, useful for identifying invasion in lung cancer
NewsLab news
A study on molecules associated with poor prognosis in lung adenocarcinoma was published in Pathology International
A paper on a treatment strategy to counter resistance to RET inhibitors was accepted by BBA - Molecular Basis of Disease
A paper on examining EGFR genotype using cfDNA from bronchial washings was accepted by JJCO
A paper on the expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinoma was published in Virchows Archiv
A review on histological transformation of lung cancer after TKI treatment was accepted by Cancer Science
ResearchResearch themes
The Diagnostic Pathology Lab conducts research directly linked to clinical practice. By comparing pathologists' observations with data such as the genetic data of cancer cell lines, the lab analyzes molecules involved in the development and progression of cancer.
*Illustrative imageAnalysis of Molecules Involved in Cancer Development and Progression
The lab observes background lesions, early lesions, and the process of progression, and compares them with the genetic data of its cancer cell lines, the tissue morphology of xenograft tumors, and drug sensitivity to analyze molecules involved in the development and progression of cancer.
*Illustrative imageEVG-Stained Specimens and an AI Diagnostic System
The lab is collecting many EVG-stained specimens, which help identify invasion in the pathological diagnosis of lung cancer, and analyzing them with AI. The research explores the possibility of building an AI diagnostic system that can make better diagnoses than those based on HE-stained specimens alone.
MembersFaculty
- ProfessorDaisuke Matsubara
- Associate ProfessorAya Shiba
- Assistant ProfessorHitomi Kawai
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pathologist” Oktay98 / CC BY-SA 4.0 (cropped)
- Analysis of Molecules Involved in Cancer Development and Progression: “Pathology department at the central cancer research laboratories” Unknown photographer / Public domain (cropped)
- EVG-Stained Specimens and an AI Diagnostic System: “Colon Adenocarcinoma, Whole-Mount Scan ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (実
験動物学): “LRDT Microscopy Micromanipulation” 作者不詳 / Public domain (cropped) - Related lab (病院診療研究G
（病理部） ): “Tissue processing - Microtome is used to cut a ribbon of 5-micron-thick sections from the paraffin block” Ed Uthman / CC BY-SA 2.0 (cropped)
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