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18 labs · 0 student voices
Other departments in School of Medicine and Health Sciences ›Faculties at University of Tsukuba ›
Satoru Takahashi, Professor
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The Anatomy and Embryology Lab uses a variety of genetically modified mice to study the molecular mechanisms underlying life phenomena and the mechanisms by which diseases arise. The lab focuses on the Maf family of transcription factors and on the functions of macrophages, a type of immune cell, and investigates the mechanisms of development and differentiation, metabolism, and disease onset. It also works on the functions of glycans and on changes in gene expression in mice raised in space. On the lab's website, it is presented under the name "Takahashi Lab."
Genta Nagae, Professor
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The Molecular Pathology Lab clarifies abnormalities in cancer cells at the molecular level, aiming to establish methods to specifically damage cancer cells. The lab focuses on transforming growth factor-β (TGF-β), which is activated in many cancer tissues, and on induction of stemness, in which some cancer cells that have stopped proliferating acquire stem cell properties. Focusing on cancer stem cells that resist treatment as a cause of metastasis and recurrence after therapy, the lab is developing treatments that target the mechanism by which induction of stemness makes cancer stem cells increase rapidly. On the lab's website, the lab is introduced under the name "Experimental Pathology Lab," and the content here is based on descriptions from around 2023.
Tadachika Koganezawa, Associate Professor
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The Neurophysiology Lab studies the regulation of blood circulation and respiratory movements in order to clarify how the brain maintains homeostasis in the body. If the brain's control of blood circulation does not work properly, it can cause serious cardiovascular diseases, so the lab works to clarify how this control actually operates. Using rodent preparations, mainly with electrophysiological methods, the lab examines in detail the brain centers that regulate circulation and breathing. The lab is recruiting graduate students to conduct research together, and also accepts undergraduate students for graduation research.
Kenji Irie, Professor
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The Molecular and Cellular Biology Lab uses budding yeast, a eukaryotic model organism, to elucidate the regulatory mechanisms of biological phenomena, aiming to contribute to medicine and healthcare. The lab works on post-transcriptional regulation of gene expression, the signaling mechanisms that control the endoplasmic reticulum (ER) stress response, and the mechanisms of gamete formation. Undergraduate students can join through graduation research in the College of Medical Sciences and the College of Biological Sciences, or through laboratory training in the College of Medicine. On the lab's website, it is introduced under the name "Irie Lab."
Ken Nishimura, Professor
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The Gene Regulation Lab studies gene expression, which lies at the foundation of biological phenomena, using biochemical and molecular biological methods. It investigates transcription factors involved in transcriptional regulation, structural remodeling of chromatin (the site of transcription), and the mechanisms of iPS cell induction. As one of its research topics, the lab also studies how brown adipocytes and beige cells differentiate, aiming to contribute to solving obesity. The lab's website states that it provides careful, individual guidance to each graduate student, regardless of which university or department they come from.
Michael LAZARUS, Professor
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The Lazarus-Oishi Lab studies the mechanisms that regulate sleep, as well as drug discovery, centered on the brain pathways linking sleep, wakefulness, and motivation. Using mice, the lab investigates how the caffeine in coffee and tea promotes wakefulness and how sleep affects immunity. In its research on sleep and motivation, the lab combines techniques for manipulating neural activity with light or drugs with in vivo imaging. The lab is located in the International Institute for Integrative Sleep Medicine (WPI-IIIS) at the University of Tsukuba and is jointly led by Professor Lazarus and Associate Professor Oishi.
Tsuyoshi Saitoh, Associate Professor
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The Medicinal Chemistry Lab (Saitoh Group) conducts research aimed at creating innovative molecules that contribute to biology and medical science, with chemistry as its foundation. Using GPCRs (G protein-coupled receptors), which are common drug targets, as a key theme, the lab carries out drug discovery research and chemical biology research on artificially controlling GPCR function. Based on the principle of "controlling living systems at will with chemistry," the lab values the curiosity behind the thought "I want to make a molecule like this!" On the lab's website, it is presented under the name "Kutsumura-Saitoh Lab."
Norihiko Ohbayashi, Associate Professor
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Associate Professor Norihiko Ohbayashi's lab studies membrane traffic, the mechanism that transports materials within cells, focusing on small GTPases (low-molecular-weight G proteins). The lab investigates the functions of small GTPases such as Rab and Arf in pigment cells (melanocytes). The entry in the university's researcher directory was last updated in August 2025. Associate Professor Ohbayashi is listed as a researcher in the graduate school's Degree Programs in Medical Sciences (Life Sciences and Medicine Domain).
Atsushi Kawaguchi, Professor
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The Molecular Virology Lab studies how influenza virus and SARS-CoV-2 interact with host cells and lead to disease in organs and severe symptoms. The lab investigates the mechanisms of infection from the molecular level at multiple stages: proteins, cells, and organs and whole organisms. The lab combines observation of cells by light microscopy, handling of highly pathogenic strains in a BSL-3 facility, animal models of infection created with genetic modification technology, and analysis of patient samples in collaboration with the affiliated hospital. Students from a variety of backgrounds, not only medicine, take part in the research.
Kazuya Morikawa, Professor
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The Microbiology Lab studies how pathogenic bacteria such as staphylococci adapt to hosts and environments, survive, and exert their pathogenicity. The main subject is Staphylococcus aureus, an opportunistic pathogen that lives as a commensal in the human nasal cavity. From perspectives such as "heterogeneity within cell populations" and "dynamics of the nucleoid and cell membrane," the lab approaches the mechanisms of drug resistance and adaptation. Students can join the lab as graduation research students from the School of Medical Sciences or the School of Biological Sciences (Human Biology course), or as master's or doctoral students.
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