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1,294 labs · 618 student voices
Hirohide Saito, Professor
Bio & Life Sciences0 student voices
The RNP Biotechnology Lab studies biological systems built on RNA and on RNPs, which are complexes in which RNA and proteins are bound together. By elucidating how RNA and RNPs work and then redesigning them artificially, the lab aims to develop technologies for manipulating cells at will. The lab works on creating new functional RNAs using AI technology and experimental evolution, and on developing next-generation iPS cells and artificial cells. The lab was launched in April 2024 at the Institute for Quantitative Biosciences, and also has a base at the Center for iPS Cell Research and Application (CiRA), Kyoto University.
Akimitsu Nobuyoshi, Professor
Bio & Life Sciences0 student voices
The lab studies the molecular functions of nucleic acids such as DNA and RNA, especially RNA, and their applications. Using molecular biology, multi-omics analysis, and molecular imaging, the lab investigates the functions of long non-coding RNAs that regulate stress responses, cancer, and innate immunity. Building on these findings, the lab is also working to develop a new platform for nucleic acid therapeutics based on the concept of "designer RNA." The lab is based at the Isotope Science Center and is also developing technology that uses radioisotopes to combine cancer diagnosis and treatment.
Yukiko Gotoh, Professor
Bio & Life Sciences0 student voices
The lab studies at the molecular level how cell fate is determined, focusing on the process by which the brain is formed. Neural stem cells in the brain proliferate while generating many types of neurons and glial cells, and these cells assemble the brain as a tissue. Focusing on the regulation of gene expression by the epigenome and by chromatin inside the nucleus, the lab investigates the mechanisms that control the fates of neural stem cells and neurons. The lab is also working to understand how abnormalities in brain development lead to conditions such as psychiatric disorders.
Yuichi Taniguchi, Professor
Bio & Life Sciences0 student voices
The Bioanalytical Chemistry Lab studies new analytical methods that capture how life works at the molecular level. By combining insights from biology, chemistry, physics, AI, and other fields, the lab captures biological phenomena that earlier methods could not reveal. The lab investigates at the molecular level why drugs work or fail to work, and the mechanisms behind how each cell responds differently to a drug. It aims to apply these results to AI-based prediction of drug response, laying the foundation for next-generation drug discovery and precision medicine.
Urano Yasuteru, Professor (Concurrent)
Chemistry & Catalysis0 student voices
The Medicinal Plant Chemistry Lab, together with the Medicinal Plant Garden affiliated with the Graduate School of Pharmaceutical Sciences, works with plants that can be used as medicine (medicinal plants). Humans have used plants as medicine since ancient times. What has been preserved through that experience is today's crude drugs. The importance of plant-derived pharmaceuticals remains unchanged, and research on plants as a source of medicines is still developing. The affiliated Medicinal Plant Garden is located next to the Kemigawa General Sports Ground, and its grounds include greenhouses and a research building.
Masayuki Inoue, Professor
Chemistry & Catalysis0 student voices
The Natural Products Synthetic Chemistry Lab studies total synthesis, the use of organic synthesis to build in full natural products that act strongly on the body. Its targets are natural products densely packed with polar functional groups, and large peptide-based natural products that may function like proteins. Even today, there is no established method for the total synthesis of such natural products. The lab develops new reactions, synthetic methods, and strategies for this purpose. The lab also aims to create new functional molecules with properties not found in natural products, as well as miniaturized proteins.
Yoshihiro Kawaoka, Project Professor
Bio & Life Sciences0 student voices
The Division of Virology (Kawaoka Lab) studies how viruses cause disease. Using influenza virus, Ebola virus, and the novel coronavirus (SARS-CoV-2) as models, the lab investigates what happens between virus and host, from the molecular level to the population level. Using animal models, electron microscopy, and reverse genetics, the lab has identified mutations that determine differences in pathogenicity and clarified how virus particles are formed. The lab also works on vaccine development and analysis of resistance to anti-influenza drugs.
Mutsuhiro Takekawa, Professor
Bio & Life Sciences0 student voices
The Disease Proteomics Lab conducts research that clarifies how diseases arise, starting from the protein level. Using advanced imaging and mass spectrometry technologies, the lab captures the dynamics of proteins in living organisms. Based on these results, the lab analyzes protein complexes and networks of functional proteins, and uses them to help elucidate disease conditions such as cancer and infectious diseases. The lab also supports research conducted at the Institute of Medical Science and is responsible for introducing and developing new analytical technologies.
Tomoji Mashimo, Professor
Bio & Life Sciences0 student voices
The Advanced Animal Genome Research Lab develops genome editing technologies and uses them to research model animals and therapies. The lab is working to apply CRISPR-Cas3, Japan's first genome editing technology, to cell therapy using human cells and to gene therapy. By performing genome editing on fertilized eggs, the lab also creates humanized animals that carry human genes, as well as disease model animals. The lab is also developing animals with humanized organs by transplanting human cells or iPS cells into immunodeficient animals.
Takashi Okada, Professor
Medicine & Healthcare0 student voices
The lab researches the development of the foundational technologies for gene therapy and cell therapy. Building on viral vector and tissue stem cell technologies, the lab advances research in gene therapy and cell therapy. Alongside analysis of molecular pathology and clinical genetics services, the lab aims to conduct translational research for personalized genomic medicine. The lab is a department based in the Center for Gene and Cell Therapy at the Institute of Medical Science Hospital; the center handles research, development, and clinical trials of treatments for intractable cancers and genetic diseases.
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