LAB LOGA page on LabLog, a review site (not the lab's official page)
Advanced Animal Genome Research Lab
Machine-translated · View original
The lab develops genome editing technologies and applies them to research on humanized animals and gene therapy.
AboutAbout the lab
Creating genome editing technology and bringing it to medicine.
The Advanced Animal Genome Research Lab develops genome editing technologies and uses them to research model animals and therapies.
The lab is working to apply CRISPR-Cas3, Japan's first genome editing technology, to cell therapy using human cells and to gene therapy.
By performing genome editing on fertilized eggs, the lab also creates humanized animals that carry human genes, as well as disease model animals.
The lab is also developing animals with humanized organs by transplanting human cells or iPS cells into immunodeficient animals.
Key terms
- Genome editing
- A technology that cuts and rewrites a targeted location in an organism's genetic information. Methods include ZFN and CRISPR.
- CRISPR-Cas3
- A genome editing tool developed in Japan by this lab. It is characterized by its ability to delete long stretches of DNA.
- Knock-in
- Inserting the sequence of another gene at a targeted location. Disrupting a gene is called a knockout.
NewsLab news
A paper on a technology that disrupts genes in human T cells using CRISPR-Cas3 was published in NAR Cancer
The lab developed an in vivo genome editing method using CRISPR/Cas3, published in Nature Biotechnology
The lab developed a portable mpox detection method using CRISPR-Cas3
A master's student won an Outstanding Poster Award at the joint Amami Symposium of the Institute of Medical Science and the Atmosphere and Ocean Research Institute
A postdoc and a doctoral student won Outstanding Poster Awards at the 10th Annual Meeting of the Japanese Society for Genome Editing
ResearchResearch themes
The lab has developed CRISPR-Cas3, a genome editing technology from Japan, and is advancing its application to cell therapy and gene therapy. It also creates model animals with human-like characteristics through genome editing of fertilized eggs and cell transplantation.
*Illustrative imageDeveloping genome editing technology from Japan
Genome editing faces challenges such as off-target mutations, in which sites other than the intended target are altered. The lab developed CRISPR-Cas3, Japan's first genome editing technology, and is working on cell therapies using human cells, iPS cells, and immune T cells; gene therapy that delivers genome editing inside the body using viral vectors; and the search for cancer genes.
*Illustrative imageCreating humanized animals
Using genome editing, the lab removes a gene from an animal and inserts a human gene (knock-in) to create animals that carry human genes. The lab also creates animals by transplanting human cells or tissues into immunodeficient animals, which makes it possible to analyze human metabolism and physiological responses inside the animal's body.
MembersFaculty
The members of the Advanced Animal Genome Research Lab consist of faculty, project researchers, collaborative researchers, doctoral and master's students, research students, technical staff, and secretaries.As of 2026
- ProfessorTomoji MashimoPublications ↗
- Associate ProfessorIshida SaekoPublications ↗
- Project Assistant ProfessorKaya Miyazaki
VoicesStudent voices
Ratings and reviews reflect the experiences of individual current or former students, not the lab's official views. Whether a lab has reviews, or how many, says nothing about the lab itself.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
Student ratings (0 students)
--
--
--
--
--
--
Student voices answer questions like these
- What's great about this lab?
- What did you learn after joining?
- What's the vibe, and what is the professor like?
- Who is this lab for?
- Where do graduates go?
Your experience can help younger students choose their lab. Your name won't be shown.
Write a lab reviewAnonymous · Your draft is saved if you stopThe information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “NHGRI-97218” Ernesto del Aguila III, NHGRI / Public domain (cropped)
- Developing genome editing technology from Japan: “XBio illustration – Cas Genes” explorebiology / CC BY 4.0 (cropped)
- Creating humanized animals: “Lab mice 436262” Understanding Animal Research / CC BY 2.0 (cropped)
About LabLog
LabLog is a lab review app for students only. Student members at each university interview students in labs and publish what they say. Student voices can only be read by students who sign up with a university email address. Operated by bestiee Inc.
Learn more about LabLog ↗Search engines and AI may reference the basic lab info and rating summaries on this page and the description of LabLog. Student voices are for student members only. Automated collection by programs (scraping, or input to or training of AI) is prohibited under Article 8 of the Terms of Service. If you need data for research or analysis, please contact us.