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26 labs · 12 student voices
Faculties at The University of Tokyo ›
Taisuke Tomita, Professor
Medicine & Healthcare1 student voices
The lab studies the pathology of neuropsychiatric diseases such as Alzheimer's disease, autism, and Parkinson's disease. Using biochemistry and molecular biology, the lab investigates what happens at the molecular and cellular levels, using both cultured cells and animal models. From this work, the lab aims to identify new drug targets and publish findings that lead to the development of therapeutics. The lab also pursues collaborative research with researchers in organic chemistry, structural biology, and clinical medicine, as well as with pharmaceutical companies.
Hiroyuki Kusuhara, Professor
Medicine & Healthcare1 student voices
The Molecular Pharmacokinetics Lab studies how drugs are absorbed, distributed, and excreted in the body. The lab investigates the factors that determine how drugs move, in particular the mechanisms by which drugs pass through cell membranes. By incorporating into mathematical models the actions of transporters, which carry substances across membranes, and of drug-metabolizing enzymes, the lab aims to predict drug efficacy and side effects from the dose. The lab also works on developing treatments for intractable pediatric liver diseases, and on research that uses computers to convert data on chemical compounds and pathology images into numerical form.
Shohei Hori, Professor
Bio & Life Sciences1 student voices
The Immunology and Microbiology Lab studies how the immune system determines "self" through its interactions with the environment. Even organisms that are genetically "non-self," such as gut bacteria, are largely judged by the immune system to be part of "self," and coexist with it rather than being eliminated. When this mechanism of immune tolerance breaks down, it leads to the onset of autoimmune diseases, inflammatory bowel disease, allergy, cancer, and infectious diseases. The lab focuses on regulatory T cells that respond to "self," aiming to elucidate the underlying principles and to apply the resulting findings to the treatment of diseases.
Toshiyuki Shimizu, Professor
Bio & Life Sciences1 student voices
The Protein Structural Biology Lab determines the three-dimensional structures of biological macromolecules such as proteins, and of their complexes, at the atomic level. Structural biology is a field that seeks to understand how molecules function and how biological phenomena arise by depicting the shapes and interactions of molecules in a visible form. Built around X-ray crystallography, the lab also incorporates small-angle X-ray scattering and single-particle analysis by cryo-electron microscopy. With applications to drug discovery in mind, the lab targets biological macromolecules that are important from medical and pharmaceutical perspectives.
Shigeo Murata, Professor
Bio & Life Sciences1 student voices
The Protein Metabolism Lab studies how the proteasome, the main protein-degradation machinery inside cells, controls cellular function. The proteasome degrades proteins tagged with ubiquitin and plays an essential role in many biological processes, including the cell cycle and signal transduction. The lab uses a wide range of approaches, including cell biology, biochemistry, mouse genetic engineering, and yeast and Drosophila genetics. The lab aims to elucidate how abnormalities in the amount or activity of the proteasome lead to diseases and conditions such as cancer, neurodegeneration, and aging.
Yuichiro Nakajima, Associate Professor
Bio & Life Sciences1 student voices
The Genetics Lab studies "plasticity of cell fate," the ability of cells to change their properties and roles in response to circumstances. Animal bodies maintain homeostasis while responding to environmental changes such as nutrition, temperature, injury, and inflammation, and plasticity underlies this ability. Plasticity is essential for an organism's adaptation, but it is also thought to be closely linked to chronic inflammation and to functional changes that accompany aging. Through comparative studies using fruit flies (Drosophila) and jellyfish, the lab seeks to uncover the common principles of plasticity in living systems.
Daiju Kitagawa, Professor
Bio & Life Sciences1 student voices
The lab aims to understand the mechanisms of cell division, which proceeds through many stages, and to develop that understanding into drug discovery, including new anticancer drugs. It focuses in particular on centrosome duplication and on how the spindle forms and segregates chromosomes. Centering on the relationship between proteins and non-coding RNAs, the lab combines a wide range of methods, including cell biology, biochemistry, structural biology, and simulation. The lab also reproduces in vitro the interactions between cells that take place in the body, in order to clarify the molecular mechanisms behind them.
Junken Aoki, Professor
Bio & Life Sciences1 student voices
The Health Chemistry Lab studies the functions of lipids and lipid-related molecules at the cellular and whole-organism levels. Biological membranes are made up of more than 1,000 types of lipid molecules, and each one is thought to have its own specific function. Because lipids are not directly encoded by genes, studying their functions is a far more difficult challenge than studying proteins. Using technologies such as mass microscopy and mass spectrometry, the lab works to clarify the functions of a wide variety of phospholipids.
Koh Takeuchi, Professor
Bio & Life Sciences1 student voices
The Biophysical Chemistry Lab studies how the molecules that sustain life move and function. Using physical chemistry methods centered on nuclear magnetic resonance (NMR), the lab observes the dynamic behavior of molecules and seeks to clarify how those molecules contribute to the workings of the body. The lab pursues "dynamic structure-based drug discovery," which actively applies the motions of proteins and RNA to drug discovery. The lab also develops new NMR methods, such as measurements of high-molecular-weight proteins and analyses inside living cells.
Masanobu Uchiyama, Professor
Chemistry & Catalysis1 student voices
The Fundamental Organic Chemistry Lab studies the properties and phenomena of matter, seeking to understand them through the "language of chemistry": molecules, atoms, and electrons. The lab develops reactions that freely control the bonds between atoms, with the aim of creating functional materials. The lab develops techniques to precisely design and synthesize molecules as small as one billionth of a meter (a nanometer) or less. Built on three pillars (synthetic organic chemistry, spectroscopy and physical chemistry, and theoretical chemistry and computational science), the lab pursues chemistry that crosses disciplinary boundaries.
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