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Disease Proteomics Lab
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A proteomics lab that reads how diseases arise from the functions of proteins.
AboutAbout the lab
Revealing the mechanisms of disease at the protein level.
The Disease Proteomics Lab conducts research that clarifies how diseases arise, starting from the protein level.
Using advanced imaging and mass spectrometry technologies, the lab captures the dynamics of proteins in living organisms.
Based on these results, the lab analyzes protein complexes and networks of functional proteins, and uses them to help elucidate disease conditions such as cancer and infectious diseases.
The lab also supports research conducted at the Institute of Medical Science and is responsible for introducing and developing new analytical technologies.
Key terms
- Proteome
- The entire set of proteins in a cell or tissue. The counterpart of the genome, which refers to the entire set of genes
- Mass spectrometry
- A method that precisely measures the mass of molecules to identify the substances present and their amounts
- Phosphorylation
- A chemical change in which a phosphate group is attached to a protein. It acts as a signal that transmits information inside the cell
ResearchResearch themes
Using highly sensitive mass spectrometry systems, the lab comprehensively analyzes proteins and their modifications inside cells. It interprets networks from the resulting large-scale data and uses them to help elucidate the mechanisms of disease.
*Illustrative imageLarge-Scale Analysis of Phosphorylation Networks
In the signal transduction that controls cell proliferation and differentiation, protein phosphorylation plays the main role. By combining highly sensitive mass spectrometry with quantification using stable isotope labeling, the lab comprehensively captures the behavior of trace amounts of signaling factors and analyzes their networks.
*Illustrative imageTranslational Control That Determines the Human Proteome
About half of human genes have a short ORF in the 5' untranslated region of their mRNA. Through proteome analysis focused on small proteins, the lab directly identifies the proteins produced from this region and investigates the mechanisms of translational control that shape the overall picture of the human proteome.
*Illustrative imageHigh-Precision Analysis of Modifications and Interactions
In collaboration with universities and research institutions inside and outside the institute, the lab is advancing high-precision proteome analysis targeting a wide range of diseases and biological phenomena, including cancer and infectious diseases. It works on identifying trace amounts of functional factors that could not be seen with conventional methods, and on determining modification sites such as phosphorylation and ubiquitination.
MembersFaculty
The members of the Disease Proteomics Lab consist of faculty members, technical specialists, academic and project specialist staff, graduate students, seconded researchers, and visiting researchers.
- ProfessorMutsuhiro TakekawaPublications ↗
- ProfessorKouhei TsumotoPublications ↗
- Associate ProfessorMasaaki OyamaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “U.S. Department of Energy - Science - )” U.S. Department of Energy from United States / Public domain (cropped)
- Large-Scale Analysis of Phosphorylation Networks: “Serine Phosphorylation” Wikimimura / CC BY-SA 4.0 (cropped)
- Translational Control That Determines the Human Proteome: “Rough ER Close up” Christinelmiller / CC BY-SA 4.0 (cropped)
- High-Precision Analysis of Modifications and Interactions: “Protein pattern analyzer” 作者不詳 / Public domain (cropped)
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