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Natural Products Synthetic Chemistry Lab
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The lab uses organic synthesis to build, in full, natural products with powerful biological activity.
AboutAbout the lab
Science that grows out of the total synthesis of bioactive natural products
The Natural Products Synthetic Chemistry Lab studies total synthesis, the use of organic synthesis to build in full natural products that act strongly on the body.
Its targets are natural products densely packed with polar functional groups, and large peptide-based natural products that may function like proteins.
Even today, there is no established method for the total synthesis of such natural products. The lab develops new reactions, synthetic methods, and strategies for this purpose.
The lab also aims to create new functional molecules with properties not found in natural products, as well as miniaturized proteins.
Key terms
- Total synthesis
- Artificially assembling a complex molecule, such as a natural product, from simple starting materials through a series of chemical reactions
- Polar functional group
- A group of atoms, such as a hydroxyl group, with an uneven distribution of electric charge that determines a molecule's properties and function
- Peptide
- A molecule in which amino acids are linked in a chain. When the chain becomes long, it forms a protein
NewsLab news
A doctoral student received an Excellent Presentation Award at the Symposium on Organic Chemistry for the Next Generation
Total synthesis of 16β-Hydroxylpseudobufarenogin published in Angew. Chem. Int. Ed.
A student received a Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
Total synthesis and functional analysis of Loihichelin C published in JACS Au
Identification of a target protein by photoaffinity labeling, in a collaborative study, published in J. Am. Chem. Soc.
ResearchResearch themes
The lab works on science that grows out of the total synthesis of bioactive natural products. It develops reactions, synthetic methods, and strategies that make the total synthesis of highly functional natural products broadly applicable, and aims to create new functional molecules based on natural products.
*Illustrative imageNatural products as the foundation of the research
The research is built on natural products densely packed with polar functional groups that act strongly on proteins and other targets, and on large peptide-based natural products. Although natural product molecules are small, their diverse ring structures and functional groups pack in a great deal of information about their activity.
*Illustrative imageTotal synthesis: recreating a natural product in full
Natural product structures are economical, and losing even a part of one often greatly reduces its activity. To use natural products in medicines and similar applications, total synthesis that completely reproduces the three-dimensional arrangement of atoms is necessary.
*Illustrative imageTotal synthesis methods and new functional molecules
To make the total synthesis of highly functional natural products broadly applicable, the lab develops reactions, synthetic methods, and strategies. Using synthetic organic chemistry that freely controls three-dimensional structure, it aims to create new functional molecules with properties not found in natural products, as well as miniaturized proteins.
MembersFaculty
The members of the Natural Products Synthetic Chemistry Lab consist of faculty, secretaries, doctoral and master's students, and undergraduates.As of 2026
- ProfessorMasayuki InouePublications ↗
- Associate ProfessorHiroaki ItohPublications ↗
- Assistant ProfessorKoichi HagiwaraPublications ↗
- Project Assistant ProfessorHaruka FujinoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Synthesis ( )” Maximilian Paradiz from Amsterdam, Netherlands / CC BY 2.0 (cropped)
- Natural products as the foundation of the research: “Octapeptin chemical structure” McGinnm4 / CC BY-SA 4.0 (cropped)
- Total synthesis: recreating a natural product in full: “Chemisches Labor” Elrond / CC BY-SA 4.0 (cropped)
- Total synthesis methods and new functional molecules: “Molymods” Sonia / CC BY 3.0 (cropped)
- Related lab (有機合成化学教室): “Rotationsverdampfer” Gmhofmann 12:13, 26. Jun. 2007 (CEST) / Public domain (cropped)
- Related lab (基礎有機化学教室): “Benzene IBO” Alicesu / CC BY-SA 4.0 (cropped)
- Related lab (薬用植物化学教室
（附属薬用植物園） ): “Benjamin Rush Medicinal Plant Garden - IMG 7239” Daderot / Public domain (cropped) - Related lab (薬化学教室): “Solutions of organic substances for NMR analysis” Ryabitskii / CC BY 4.0 (cropped)
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