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RNP Biotechnology Lab
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The lab designs complexes of RNA and proteins to manipulate cells at will.
AboutAbout the lab
Building biological systems with RNA and RNPs.
The RNP Biotechnology Lab studies biological systems built on RNA and on RNPs, which are complexes in which RNA and proteins are bound together.
By elucidating how RNA and RNPs work and then redesigning them artificially, the lab aims to develop technologies for manipulating cells at will.
The lab works on creating new functional RNAs using AI technology and experimental evolution, and on developing next-generation iPS cells and artificial cells.
The lab was launched in April 2024 at the Institute for Quantitative Biosciences, and also has a base at the Center for iPS Cell Research and Application (CiRA), Kyoto University.
Key terms
- RNP
- A complex formed by RNA and proteins bound together. It is involved in processes such as regulating gene function.
- Experimental evolution
- A method of evolving molecules with desired properties by repeating mutation and selection in test tubes or inside cells.
- iPS cells
- Pluripotent stem cells that can turn into a variety of cell types, created by adding factors to cells from the body.
NewsLab news
A doctoral student received the Excellence Award (oral presentation) at the 26th Annual Meeting of the RNA Society of Japan
A paper by a doctoral student and researchers at the Center for iPS Cell Research and Application, Kyoto University, was published in Nature Communications
A master's student received the Poster Award at the 4th Young Researchers' Meeting of Transcendent Molecular Systems
Project Assistant Professor Sumi received the 41st Inoue Research Award for Young Scientists
The RNP Biotechnology lab was launched at the Institute for Quantitative Biosciences
ResearchResearch themes
RNA and RNPs play a central role in biological systems, but much remains unknown about how they regulate life. Through research on RNA and RNPs, the RNP Biotechnology Lab aims to understand how cells and life are put together and to create new technologies.
*Illustrative imageCreating RNAs and RNPs with new functions
Using synthetic biology, AI technology, and experimental evolution, the lab aims to create RNAs and RNPs with new functions. It is also developing deep generative models that help design the sequences of functional RNAs.
*Illustrative imageDeveloping next-generation iPS cells and artificial cells
The lab is developing RNA-based technologies for efficiently generating and differentiating iPS cells, as well as technologies for selecting and purifying iPS cells. It also aims to turn artificial cells carrying genetic circuits into tools for new therapies.
MembersFaculty
The members of the RNP Biotechnology Lab consist of faculty, researchers, academic specialists, technical specialists, doctoral and master's students, secretaries, and administrative assistants.As of 2026
- ProfessorHirohide Saito
- LecturerTatsuyuki YoshiiPublications ↗
- Project LecturerYoshihiko Fujita
- Assistant ProfessorHiroki Ono
- Assistant ProfessorSeiichi Hirano
- Project Assistant ProfessorShunsuke Sumi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Ribonucleoprotein motif” 1IBM is from: http://www.pdb.org/pdb/explore/explore.do?structureId=1IBM, Ogle, J.M., Brodersen, D.E. Clemons Jr., W.M., Tarry, M.J., Carter, A.P., Ramakrishnan, V. (2001) Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science, 292: 897-902. Image created in PyMol. / Public domain (cropped)
- Creating RNAs and RNPs with new functions: “VS ribozyme dimer 4r4v” Thomas Shafee / CC BY 4.0 (cropped)
- Developing next-generation iPS cells and artificial cells: “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
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