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Bioanalytical Chemistry Lab
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A lab that uses single-molecule measurement and AI to decipher how the genome and cells function.
AboutAbout the lab
Logically understanding the complex behavior of life
The Bioanalytical Chemistry Lab studies new analytical methods that capture how life works at the molecular level.
By combining insights from biology, chemistry, physics, AI, and other fields, the lab captures biological phenomena that earlier methods could not reveal.
The lab investigates at the molecular level why drugs work or fail to work, and the mechanisms behind how each cell responds differently to a drug.
It aims to apply these results to AI-based prediction of drug response, laying the foundation for next-generation drug discovery and precision medicine.
Key terms
- Nucleosome
- The basic structural unit of the genome, formed when DNA wraps around proteins called histones
- Single-molecule microscopy
- A microscopy method that makes it possible to distinguish and observe molecules inside cells one at a time
- mRNA
- A molecule that carries a copy of a gene's information. Cells use it as a template to make proteins
NewsLab news
Paper by a Project Researcher published in Nature Communications
Paper by Professor Taniguchi and colleagues published in Nature Communications
Paper by Professor Taniguchi and colleagues published in PLOS One
ResearchResearch themes
The lab develops original analytical technologies that combine physics, chemistry, and information science, and applies them to AI-based prediction of genome function and analysis of cell states. Its goal is to create methodologies not only for understanding life but also for predicting and controlling it.
*Illustrative imageElucidating How the Genome Works
The lab examines the structure of the genome at the molecular level to clarify the physical and chemical mechanisms by which genes function. Using its original Hi-CO method, it analyzes the three-dimensional arrangement of nucleosomes across the entire genome.
*Illustrative imageOperating Principles of Cellular Systems
The lab develops methods to comprehensively and quantitatively determine which molecules each individual cell is made of. Applying single-molecule microscopy, it works on quantifying proteins and mRNA within a single cell with single-molecule sensitivity.
*Illustrative imagePredicting Drug Effects with AI
Based on the vast amount of molecular information obtained by measuring genomes and cells, the lab models cellular molecular systems using AI and mathematical theory. It aims to build the foundation for AI that predicts how cell properties change when drugs are applied or genes are manipulated.
MembersFaculty
The members of the Bioanalytical Chemistry Lab consist of faculty, project researchers, graduate students, visiting research students from other universities, undergraduate students, and secretarial staff.As of 2026
- ProfessorYuichi TaniguchiPublications ↗
- Associate ProfessorMasae OhnoPublications ↗
- Assistant ProfessorKim SooyeonPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nikon-Inverted fluorescence microscope” ArthurLau1997 / CC BY 4.0 (cropped)
- Elucidating How the Genome Works: “2005 Biosites-nucleus” David Goodsell / CC BY 4.0 (cropped)
- Operating Principles of Cellular Systems: “Co-transfected HPCA-mTFP1 and EYFP-Mem HEK 293 cells” Borys Olifirov / CC BY 4.0 (cropped)
- Predicting Drug Effects with AI: “Artificial Neural Network with Chip” mikemacmarketing / photo on flickr / CC BY 2.0 (cropped)
- Related lab (Ota Lab): “Flow Cytometer (NIH BioArt 160)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Biophysical Chemistry Lab): “NMR Spectrometer” Mgianino / CC BY 3.0 (cropped)
- Related lab (Health Chemistry Lab): “Applied Biosystems 4000 QTrap Mass Spectrometer (detail) (11)” Hey Paul from Sacramento, CA, USA / CC BY 2.0 (cropped)
- Related lab (Fundamental Organic Chemistry Lab): “Benzene IBO” Alicesu / CC BY-SA 4.0 (cropped)
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