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32 labs · 0 student voices
Faculties at The University of Osaka ›
Takeshi Kobayashi, Professor
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The Viral Immunology Division (Kobayashi Lab) studies viruses of the order Reovirales, such as rotavirus and bat-derived reovirus, and norovirus of the family Caliciviridae. Using reverse genetics, a technique for artificially constructing and manipulating viral genes, the lab investigates how viruses replicate and how they cause disease. The lab is also considering research that puts viruses to use, such as developing virus-based therapeutics and vaccine vectors. The lab is located in the Research Institute for Microbial Diseases, Osaka University, and accepts graduate students from the Graduate School of Medicine and the Graduate School of Frontier Biosciences.
Yoshiharu Matsura, Professor
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The Virus Control Group (Matsura Lab) studies viruses with pandemic potential. Viruses are organisms that can multiply only inside living cells, and to the cell they are unwelcome guests. Focusing on hepatitis C virus, the lab investigates how viruses multiply inside cells, cause disease, and evade the immune system. The lab belongs to the Center for Infectious Disease Education and Research and the Research Institute for Microbial Diseases at the University of Osaka, and brings together people from varied backgrounds such as agriculture, medicine, engineering, and science.
Tetsuya Tetsuya, Professor
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The Malaria Vaccine Development Group (Horii Lab) is developing a highly effective vaccine against falciparum malaria for practical use. At the same time, the lab analyzes the molecular mechanisms of the antigen genes that underpin the vaccine, aiming to apply its findings in vaccine development. Falciparum malaria infects many people worldwide and causes many deaths, and the spread of drug-resistant strains is also a problem. The lab belongs to the Research Center for Intractable Infectious Diseases and conducts its research as the Endowed Department for Malaria Vaccine Development.
Masaharu Iwasaki, Project Associate Professor
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The Emerging Viral Diseases Research Group (Iwasaki Lab) studies emerging viruses, with a focus on Lassa virus. Lassa virus has a high fatality rate, and there is no established treatment or preventive measure. Using approaches from virology, immunology, and RNA biology, the lab aims to elucidate how viruses multiply and how they cause disease. The lab also pursues applied research that uses its findings to develop new diagnostic methods, treatments, and preventive measures.
Kentaro Tsukamoto, Project Associate Professor
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The Zoonotic Bacterial Infections Research Group (Tsukamoto Lab) studies pathogenic bacteria that cause zoonotic infections. Focusing on Bartonella, the cause of cat-scratch disease, the lab investigates why cats do not become ill but humans do (host specificity). The lab focuses on the increase in blood vessels that occurs during infection (angiogenesis) and aims to clarify how factors produced by the bacteria work. The lab accepts graduate students from the Graduate School of Medicine, and welcomes visits from students of any background, including medicine, agriculture, and science.
Ryuichiro Abe, Project Associate Professor
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The Pathogenic Bacteria Research Group (Abe Lab) analyzes the interrelationships among pathogenic bacteria, the host immunity that acts against them, and antimicrobial drugs. Its goal is to contribute to proposing better diagnostic methods and treatment guidelines. The lab studies the humoral bactericidal factors that act when bacteria enter the bloodstream, and the individual differences among pathogens. The lab is also jointly carrying out research that uses genome analysis results of carbapenem-resistant bacteria collected in Thailand.
Tetsuya Tetsuya, Professor
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The Bacterial Infection Division studies enteric infections and emerging and re-emerging infectious diseases that occur in Thailand through pathogen detection and epidemiological investigation. It is a division of the Japan–Thailand Research Collaboration Center on Emerging and Re-emerging Infections, and works with the Department of Medical Sciences of the Ministry of Public Health of the Kingdom of Thailand and the Division of Epidemiology of the Ministry's Department of Disease Control. Targeting patients with severe diarrheal diseases, including cholera, the division is working on early detection of the causative pathogens and on developing testing methods and preventive measures. It aims for its research results to be useful not only within Thailand but also for infectious disease control in neighboring Asian countries and Japan.
Takeshi Kobayashi, Professor (Concurrent)
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The lab studies viral intestinal infections and mosquito-borne infections that recur in Asian countries, including Thailand and Japan. As a division of the Japan-Thailand Joint Research Center for Infectious Diseases, the lab carries out its research together with researchers at the Department of Medical Sciences, Ministry of Public Health of the Kingdom of Thailand. Among mosquito-borne viruses, the lab focuses on antibody-dependent enhancement (ADE) of dengue virus infection. For intestinal infections, the lab studies norovirus, a cause of acute gastroenteritis, aiming to track changes in circulating strains and to clarify its life cycle.
Tetsuya Tetsuya, Professor
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As a division of the Japan-Thailand Joint Research Center for Infectious Diseases, the lab studies resistant bacteria that antibiotics cannot kill. Its central focus is carbapenem-resistant Enterobacteriaceae (CRE), which are resistant to carbapenem antibiotics, regarded as last-resort drugs for intractable infections. With the cooperation of core hospitals in Thailand and Myanmar, the lab collects clinical isolates of CRE and sequences their genomes. Using the resulting information, the lab aims to clarify how CRE acquire drug resistance genes and how they spread.
Takeshi Kobayashi, Center Director and Professor
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The Osaka-Mahidol Infectious Diseases Center conducts research toward developing point-of-care diagnostics for mosquito-borne viral diseases. Dengue fever and chikungunya fever are mosquito-borne viral infections that are epidemic mainly in tropical and subtropical regions, including the Kingdom of Thailand. Analyses of clinical specimens are carried out jointly with the Faculty of Tropical Medicine, Mahidol University, and research has begun to clarify the relationship between viruses and the factors that make disease severe. Through this joint research, the center also puts effort into training infectious disease researchers at the Faculty of Tropical Medicine, Mahidol University, and in Japan.
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