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Other departments in Research Institute for Microbial Diseases ›Faculties at The University of Osaka ›

Sho Yamasaki, Professor
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The Yamasaki Lab studies immune receptors, which, within the immune system that protects the body, detect the invasion of foreign pathogens and abnormalities in the body. The lab has identified members of the lectin receptor family that recognize pathogens and damaged self components, and was the first to discover a group of receptors that recognize components of Mycobacterium tuberculosis. It also studies how T cells are selected in the thymus and how T cells respond to SARS-CoV-2.

Shizuo Akira, Project Professor
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The Akira Lab focuses its research on innate immunity. Innate immunity is a defense mechanism of the body that is activated at the earliest stage when pathogenic microorganisms invade, and that acts in triggering inflammatory responses and in establishing adaptive immunity. The lab has studied how pathogens are recognized by receptors such as Toll-like receptors (TLRs), as well as the intracellular signaling pathways involved. It now focuses on immune regulation through mRNA stability, aiming to clarify immunometabolism and the causes of various immune diseases and to establish new therapies.

Hisashi Arase, Professor
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The Immunochemistry Lab studies why the immune system, which evolved to protect the body from infection, can malfunction and cause abnormalities such as autoimmune diseases. The lab focuses on molecules that regulate the function of immune cells and examines how these molecules interact with the body's own molecules and with pathogens. It uses approaches such as genetically modified mice, single-cell analysis, and RNA-seq. The lab aims to uncover the causes behind questions such as why some people develop autoimmune diseases or cancer, and why some people become severely ill from infections.

Yoshiko Murakami, Project Professor
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The Glycan Immunology Lab studies how GPI-anchored proteins on the cell surface are made and what they do. GPI-anchored proteins are proteins attached to the cell membrane by the glycolipid GPI, and they include enzymes, receptors, and adhesion molecules. If GPI is not made in the correct structure and in the necessary amount, a disease called GPI deficiency results, so the lab aims to clarify its pathology and apply this to diagnosis and treatment.

Tetsuya Tetsuya, Professor
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The Immunometabolism Lab studies metabolism and immune cells in the body, where multiple organs work in coordination. The lab examines the role that metabolic signals play inside immune cells, and how immune cells affect whole-body metabolism. It also studies the roles that metabolic signals play in various types of cells. The lab belongs to the Department of Host Defense at the Research Institute for Microbial Diseases.
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