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Faculties at Chiba University ›
Yuzuru Ikehara, Professor
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The Tumor Pathology Lab pursues basic research in experimental pathology and human pathology, as well as applied research on developing treatments and diagnostic and therapeutic devices. As the former First Department of Pathology, the lab has been in charge of the autopsies performed at Chiba University for more than 100 years. The lab introduced semiconductor manufacturing and processing techniques into the preparation of pathological specimens and developed a method for detecting pathogenic microorganisms with an electron microscope. In collaboration with plastic surgery and immunology, the lab showed that fibroblasts that sense mechanical stimulation are involved in keloid recurrence.
Shinichiro Motohashi, Professor
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The Immune Cell Medicine Lab views cancer as a disease caused by a breakdown of the immune system, and studies therapies that manipulate immunity. The lab's core work is immunotherapy using NKT cells, which has been developed at Chiba University. The work has moved from basic research to clinical research, and the therapy is now being developed under the Category 3 Advanced Medical Care framework set by the Ministry of Health, Labour and Welfare. The lab aims to establish a method of analyzing clinical research results through basic research and reflecting them in the therapies under development.
Naohiko Seki, Associate Professor
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The Functional Genomics Lab, which operates as the microRNA Research Network, has studied microRNAs since early on. The lab builds expression profiles of microRNAs in cancer cells and examines their functions through experiments. So far, it has completed profiles for head and neck cancer, esophageal cancer, lung cancer, urothelial cancer, renal cancer, and prostate cancer. Focusing on the fact that a single microRNA regulates many genes, the lab is elucidating new molecular networks formed by tumor-suppressive microRNAs and groups of oncogenes.
Katsuhiro Uzawa, Professor
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The Oral Science Lab has a history of more than 100 years, beginning in 1918 when a dental clinic was opened in the Second Department of Surgery at Chiba Prefectural Hospital. At the Graduate School of Medicine it operates as "Oral Science," and at the University Hospital as "Dentistry, Oral and Maxillofacial Surgery." At the hospital, the lab covers not only oral surgery but also a wide range of care, including general dental treatment and dental care for patients with systemic diseases. At the graduate school, the lab carries out basic research centered on cancer, as well as research aimed at regenerating teeth and salivary glands.
Toyoyuki Hanazawa, Professor
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The Otorhinolaryngology and Head and Neck Oncology Lab was founded in 1907 and has more than 100 years of history. Otorhinolaryngology deals with diseases that affect bodily functions such as hearing, smell, voice production, and swallowing. In head and neck oncology, the lab treats malignant tumors that impair not only appearance but also bodily functions, and is developing treatments that are minimally invasive and highly curative. To develop new therapeutic drugs, the lab advances immune cell therapy and genetic analysis jointly with labs inside and outside the university, and it also works on developing treatments for allergic diseases.
Takashi Uno, Professor
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The Diagnostic Imaging and Radiation Oncology Lab covers both diagnostic imaging and radiation therapy, the two pillars of radiology. Rather than dividing the lab into diagnosis and treatment, it has specialist physicians in each field and engages in clinical work, research, and education. In diagnostic imaging, the lab conducts clinical research using medical equipment such as high-field MRI, MDCT, and PET. In radiation therapy, the lab has led radiation therapy in Japan with high-precision treatments such as stereotactic irradiation and intensity-modulated radiation therapy (IMRT).
Izumi Ohno, Lecturer
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The Clinical Oncology Lab studies medical oncology, which treats cancer comprehensively regardless of the organ involved. At Chiba University Hospital, the lab serves as the medical oncology service and is in charge of cross-organ cancer care centered on chemotherapy and molecularly targeted therapy. In basic research, the lab aims to clarify, from the perspective of RNA function, how malignant tumors acquire drug resistance and heterogeneity. Through clinical research and clinical trials in cooperation with other clinical departments, the lab also works to develop new cancer treatments.
Takashi Miki, Professor
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The Metabolic Physiology Lab studies how glucose and energy metabolism are regulated. Using molecular biology and developmental engineering approaches, the lab analyzes biological phenomena at the molecular, cellular, organ, and whole-body levels. The lab approaches glucose metabolism from two sides: how insulin, which lowers blood glucose, is secreted from pancreatic β cells, and how insulin acts in peripheral tissues. The lab aims to clarify the pathophysiology of metabolic diseases such as diabetes and obesity and to establish new treatments.
Keiichiro Ishiguro, Professor
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The Disease and Life Medicine Lab studies the development of germ cells, the precursors of eggs and sperm, and the mechanisms of meiosis. Based on mouse molecular genetics, the lab combines biochemical methods, mass spectrometry, omics analysis using next-generation sequencing, and image analysis. Using factors that determine the initiation of meiosis as clues, the lab investigates how meiosis and germ cell development are coordinated. The lab aims to clarify the causes of infertility and to generate basic knowledge that can bridge to clinical application.
Tetsuichiro Saito, Professor
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The Developmental and Regenerative Medicine Lab studies how the nervous system is formed. Most neurons are generated during the fetal period, after which neural stem cells become able to generate only a limited range of cell types. The lab studies the mechanisms that operate in young neural stem cells and explores ways to halt their aging or rejuvenate them. The lab aims to build a molecular foundation for advancing regenerative medicine and to lead to the development of new therapies.
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