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Tumor Pathology Lab
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A lab that uncovers how diseases arise through autopsy and new observation techniques.
AboutAbout the lab
Contributing to society through basic and applied research.
The Tumor Pathology Lab pursues basic research in experimental pathology and human pathology, as well as applied research on developing treatments and diagnostic and therapeutic devices.
As the former First Department of Pathology, the lab has been in charge of the autopsies performed at Chiba University for more than 100 years.
The lab introduced semiconductor manufacturing and processing techniques into the preparation of pathological specimens and developed a method for detecting pathogenic microorganisms with an electron microscope.
In collaboration with plastic surgery and immunology, the lab showed that fibroblasts that sense mechanical stimulation are involved in keloid recurrence.
Key terms
- Autopsy
- An examination of the body of a deceased person to confirm the cause of death and to understand how a disease arose
- Scanning electron microscope
- A microscope that directs a fine electron beam at a sample to observe the shape of its surface at high magnification
- Keloid
- A skin condition in which a scar becomes red and raised, keeps spreading, and is difficult to heal
NewsLab news
Press release on research findings about keloid recurrence and mechanosensitive fibroblasts
Paper on PIEZO2 in keloids published in The Journal of Pathology
Review article on nanoimaging by plasma reaction published in the Japanese journal Saibo (Cell)
A graduate student received a Best Presentation Award at an international conference
ResearchResearch themes
The lab pursues both basic research in experimental pathology and human pathology, and applied research on developing treatments and diagnostic and therapeutic devices. Using specimens preserved from autopsies, semiconductor processing techniques, and near-infrared imaging, it is creating new diagnostic methods.
*Illustrative imageGross Pathology with Near-Infrared Imaging
This research uses a near-infrared imaging device to image organs removed during autopsy, aiming to create new gross diagnostic techniques and diagnostic tools.
*Illustrative imageA Database of Pathogenic Microorganisms
Semiconductor manufacturing and processing techniques are introduced into the preparation of pathological specimens, and pathogenic microorganisms are detected using a scanning electron microscope and quantitative energy-dispersive X-ray spectroscopy (EDS) analysis. The lab compiles the detected microorganisms into a database, aiming to advance the diagnosis of infectious diseases.
*Illustrative imageKeloids and Fibroblasts
In collaboration with plastic surgery and immunology, the lab found that fibroblasts with high PIEZO2 expression appear in keloid tissue. Based on this finding, the lab is building a keloid mouse model using spatial transcriptomics and established cell lines.
MembersFaculty
The members of the Tumor Pathology Lab are faculty, technical staff, lab administrative staff, and graduate students, undergraduate students, and research students.
- ProfessorYuzuru Ikehara
- Assistant ProfessorSanae Ikehara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Scanning electron microscope - UFCH JH (2020) 01” Tadeáš Bednarz / CC BY-SA 4.0 (cropped)
- Gross Pathology with Near-Infrared Imaging: “Histologic Slide under MIcroscope” Ed Uthman from Houston, TX, USA / CC BY-SA 2.0 (cropped)
- A Database of Pathogenic Microorganisms: “Leptospira scanning micrograph” CDC/ Rob Weyant / Public domain (cropped)
- Keloids and Fibroblasts: “Microtubules in Primary Mouse Embryonic Fibroblasts” Howard Vindin / CC BY 4.0 (cropped)
- Related lab (Bacterial Pathogen Control Lab): “Escherichia coli O157-H7 CDC ID-10071” CDC / Janice Haney Carr / Public domain (cropped)
- Related lab (Emergency and Critical Care Medicine Lab): “20250808 Intensive care unit bed” Ismael Olea / CC BY 4.0 (cropped)
- Related lab (Innovative Regenerative Medicine Lab): “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Hematology Lab): “Connective Tissue Human Blood Leukocyte Survey ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
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