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Clinical Oncology Lab
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A medical oncology lab working on drug therapy for cancer across all organs.
AboutAbout the lab
A new approach to cancer care that crosses organ boundaries.
The Clinical Oncology Lab studies medical oncology, which treats cancer comprehensively regardless of the organ involved.
At Chiba University Hospital, the lab serves as the medical oncology service and is in charge of cross-organ cancer care centered on chemotherapy and molecularly targeted therapy.
In basic research, the lab aims to clarify, from the perspective of RNA function, how malignant tumors acquire drug resistance and heterogeneity.
Through clinical research and clinical trials in cooperation with other clinical departments, the lab also works to develop new cancer treatments.
Key terms
- Epithelial-mesenchymal transition
- A change in which epithelial cells alter their shape and properties and become more motile. It is involved in cancer invasion and metastasis.
- RNA-binding proteins
- Proteins that bind to RNA and regulate its function and amount.
- RNA modification
- Chemical marks attached to the bases of RNA. They regulate RNA function and stability.
ResearchResearch themes
The lab conducts research across a broad range, from basic science to clinical practice. It uncovers the mechanisms that give rise to resistance and heterogeneity in malignant tumors through RNA biology, and in the clinic it studies the diagnosis and treatment of various malignant tumors jointly with other clinical departments.
*Illustrative imageRNA-Binding Proteins and Cancer
The lab investigates, from molecular biology, biochemistry, and clinical perspectives, how epithelial-mesenchymal transition and cancer stem cells, which are involved in cancer invasion and metastasis, relate to RNA-binding proteins and chemical modifications of mRNA.
*Illustrative imageOvercoming Epithelial-Mesenchymal Transition
In thoracic malignant tumors, the lab has reported that overcoming epithelial-mesenchymal transition restores drug sensitivity. It is searching for drugs that can overcome it using RNA biology and compound screening.
*Illustrative imageRNA Modifications under Stress
RNA modifications are attracting attention as a layer that regulates translation efficiency, localization, and stability. The lab analyzes their conservation and plasticity under stress such as inflammation and heat, and in extreme environments such as microgravity and low temperature.
*Illustrative imageMulticenter Clinical Research
Jointly with the departments of respiratory medicine, respiratory surgery, dentistry and oral surgery, and otorhinolaryngology, the lab conducts research on the diagnosis and treatment of various malignant tumors, and it also participates in multicenter collaborative studies and clinical trials.
MembersFaculty
The members of the Clinical Oncology Lab consist of faculty.As of 2025
- LecturerIzumi Ohno
- Clinical LecturerKoji Takahashi
- Project LecturerRyota Kurimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chemotherapy drug” Larry Ostby (Photographer) / Public domain (cropped)
- RNA-Binding Proteins and Cancer: “Gel Electrophoresis” Nik.vuk / CC BY-SA 4.0 (cropped)
- Overcoming Epithelial-Mesenchymal Transition: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- RNA Modifications under Stress: “Biochemistry laboratory MPI-CBG-panorama” Masur / CC BY-SA 3.0 (cropped)
- Multicenter Clinical Research: “Northern Centre for Cancer Care Freeman Hospital Newcastle upon Tyne” Ian Porter / CC BY-SA 2.0 (cropped)
- Related lab (Diagnostic Pathology Lab): “Pathology department at the central cancer research laboratories” Unknown photographer / Public domain (cropped)
- Related lab (Oral Science Lab): “Beneath the surface- unfiltered moments of oral surgery (8036055)” U.S. Air Force photo by Staff Sgt. Jacob Wongwai / Public domain (cropped)
- Related lab (Pathophysiology and Pathology Lab): “Charity Hospital Pathology Dept 1889 NOLA” Photographer not credited / Public domain (cropped)
- Related lab (Molecular Pathophysiology and Analysis Lab): “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
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