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Functional Genomics Lab
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The lab uncovers the molecular networks of cancer by studying microRNAs.
AboutAbout the lab
Among the first to take up microRNA as a research subject.
The Functional Genomics Lab, which operates as the microRNA Research Network, has studied microRNAs since early on.
The lab builds expression profiles of microRNAs in cancer cells and examines their functions through experiments.
So far, it has completed profiles for head and neck cancer, esophageal cancer, lung cancer, urothelial cancer, renal cancer, and prostate cancer.
Focusing on the fact that a single microRNA regulates many genes, the lab is elucidating new molecular networks formed by tumor-suppressive microRNAs and groups of oncogenes.
Key terms
- microRNA
- A short single-stranded RNA of 19–22 nucleotides that suppresses the activity of protein-coding genes
- Expression profile
- A comprehensive list of which molecules are made in a cell, and in what amounts
- Tumor-suppressive microRNA
- A microRNA that is reduced in cancer cells and, when active, suppresses the proliferation and metastasis of cancer cells
ResearchResearch themes
The lab comprehensively investigates how microRNA expression changes in cancer cells and confirms their functions through experiments. Its goal is to uncover the molecular networks that tumor-suppressive microRNAs form with groups of oncogenes.
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MembersFaculty
The members of the Functional Genomics Lab are faculty and graduate students.
- Associate ProfessorNaohiko Seki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “3a6p xpo5 ran miRNA” Opabinia regalis / CC BY-SA 3.0 (cropped)
- Exploring Molecular Networks in Lung Cancer: “Small cell lung carcinoma vs. benign mesothelial cells ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse MOB three color” Matt Valley / Public domain (cropped)
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