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Otorhinolaryngology and Head and Neck Oncology Lab
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The lab works to protect hearing, smell, speech, and swallowing while taking on head and neck cancer.
AboutAbout the lab
A development center for head and neck surgery with more than 100 years of history.
The Otorhinolaryngology and Head and Neck Oncology Lab was founded in 1907 and has more than 100 years of history.
Otorhinolaryngology deals with diseases that affect bodily functions such as hearing, smell, voice production, and swallowing.
In head and neck oncology, the lab treats malignant tumors that impair not only appearance but also bodily functions, and is developing treatments that are minimally invasive and highly curative.
To develop new therapeutic drugs, the lab advances immune cell therapy and genetic analysis jointly with labs inside and outside the university, and it also works on developing treatments for allergic diseases.
Key terms
- Head and neck
- The area from the nose, mouth, and throat to the neck, where the functions of eating, speaking, and breathing come together.
- Sublingual immunotherapy
- Treatment in which an extract of the allergy-causing substance is placed under the tongue to make the body less likely to react.
- NKT cells
- Lymphocytes with strong anticancer activity. The mechanism of their activation was discovered at Chiba University.
NewsLab news
A Project Lecturer received the Best Oral Presentation Award at an international symposium on salivary glands
A graduate student's paper was published in American Journal of Otolaryngology
Assistant Professor Kawase received the Chiba Medical Society Encouragement Award
Project Lecturer Nakagawa received the Young Investigator Award at the 127th Annual Meeting of the Oto-Rhino-Laryngological Society of Japan
Lecturer Iinuma's paper was accepted by Nature Communications
ResearchResearch themes
The lab is developing minimally invasive, highly curative treatments for malignant tumors of the head and neck. It also studies new treatments for allergic rhinitis, including Japanese cedar pollinosis.
*Illustrative imageSublingual Immunotherapy for Rhinitis
The lab has researched sublingual immunotherapy for Japanese cedar pollinosis since 2005, and it opened a sublingual immunotherapy outpatient clinic in 2014. It is searching for biomarkers that can confirm through blood tests whether the treatment is working.
*Illustrative imageImmune Cell Therapy for Head and Neck Cancer
Together with the Department of Immunology at Chiba University and RIKEN, the lab is developing treatment using NKT cells, which have strong anticancer activity. Clinical trials have been repeated since 2005, and for head and neck squamous cell carcinoma the therapy was approved as Advanced Medical Care in 2013. Currently, the lab is conducting a clinical trial in which NKT cells made from iPS cells are administered directly into the cancer.
*Illustrative imageChecking Symptoms with an App
In international joint research with ARIA, the international guideline initiative on allergic rhinitis from Europe, the lab records daily symptoms with the smartphone app MASK-air and analyzes the effects and characteristics of treatment.
MembersFaculty
The members of the Otorhinolaryngology and Head and Neck Oncology Lab consist of faculty, staff physicians, and graduate students.
- ProfessorToyoyuki Hanazawa
- Associate ProfessorSyuji Yonekura
- LecturerTomohisa Iinuma
- Assistant ProfessorTomoyuki Arai
- Assistant ProfessorKeiichi Koshizuka
- Project LecturerTakuya Nakagawa
- Assistant ProfessorRiyo Yoneda
- Assistant ProfessorJunya Kurita
- Assistant ProfessorKatsushige Kawase
- Project Associate ProfessorTakeshi Suzuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CT scan of the paranasal sinuses 138” Wilfredor / CC BY-SA 4.0 (cropped)
- Sublingual Immunotherapy for Rhinitis: “Blausen 0015 AllergicRhinitis” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Immune Cell Therapy for Head and Neck Cancer: “Human Natural Killer Cell ( )” NIAID / CC BY 2.0 (cropped)
- Checking Symptoms with an App: “Personal Health Apps for Smartphones” Intel Free Press / CC BY 2.0 (cropped)
- Related lab (口腔科学): “Beneath the surface- unfiltered moments of oral surgery (8036055)” U.S. Air Force photo by Staff Sgt. Jacob Wongwai / Public domain (cropped)
- Related lab (細胞分子医学): “Molecular Biology Laboratory, reflections - geograph.org.uk - 3763234” John Sutton / CC BY-SA 2.0 (cropped)
- Related lab (精神医学): “Mental Health clinic adapts to 52nd FW needs during COVID- )” U.S. Air Force photo by Senior Airman Kyle Cope / Public domain (cropped)
- Related lab (免疫細胞医学): “Лаборант готовит индивидуальный иммунологический препарат против рака из крови пациента” Иоанна Чернова / CC BY 4.0 (cropped)
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