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10 labs · 1 student voices
Other departments in Center for iPS Cell Research and Application ›Faculties at Kyoto University ›
Akitsu Hotta, Associate Professor
1 student voices
It is said that genetic mutations are involved in more than half of the intractable diseases that are difficult to treat. Technologies that repair genes and patient-derived iPS cells are powerful tools for developing new treatments for intractable diseases caused by genetic mutations. The Hotta Lab focuses mainly on muscular dystrophy and develops a variety of technologies, including gene repair by genome editing, delivery into the body, and creation of cells that avoid immune rejection.
Kenji Osafune, Professor
0 student voices
For intractable diseases of the kidney, pancreas, and liver, such as chronic kidney disease, diabetes, and cirrhosis, there is a serious shortage of donor organs for transplantation, which is the curative treatment. The Osafune Lab studies how to regenerate kidneys, pancreases, and livers from human iPS cells, producing cells and organs usable for transplantation as well as new therapeutic drugs. Drawing on knowledge of developmental biology, the lab has established methods to efficiently differentiate iPS cells into the cells that form these three organs.
Haruhisa Inoue, Professor
0 student voices
With the arrival of a super-aged society, the number of patients with intractable neurological diseases and dementia is growing. For intractable neurological diseases such as ALS and Alzheimer's disease, there are still no fundamental treatments that completely halt progression. The Inoue Lab aims to establish fundamental treatments for intractable neurological diseases by using patients' iPS cells in both directions: from research on disease mechanisms and therapies to clinical trials, and from clinical trials back to that research.
Shin Kaneko, Professor
0 student voices
The Kaneko Lab conducts research toward immune regenerative therapy that takes advantage of the properties of iPS cells. iPS cells made from T cells retain the receptor gene sequences of the original T cell. Using this feature, the lab established a method to produce large numbers of rejuvenated T cells that recognize a targeted antigen. The lab aims to contribute to the realization of regenerative medicine and to better treatment outcomes in cancer, infectious diseases, autoimmune diseases, and transplantation medicine.
Jun Saito, Professor
0 student voices
The Saito Lab uses disease-specific iPS cells made from the cells of patients with rare, hard-to-treat diseases to analyze disease mechanisms and develop treatments. Many rare intractable diseases that begin in childhood have unknown causes and no known treatments, and the suffering can last a lifetime. For diseases that cannot be studied adequately in mice or cultured cells, using patients' iPS cells is effective. The lab mainly targets immune diseases (immunodeficiencies and autoinflammatory syndromes), blood diseases (such as bone marrow failure), and neuromuscular diseases (spinal muscular atrophy).
Shimpei Gotoh, Professor
0 student voices
The respiratory system is divided into two regions: the airways and the alveoli. The airways perform mucociliary clearance, which removes foreign particles and pathogens, while the alveoli perform gas exchange of oxygen and carbon dioxide. The Gotoh Lab develops technologies to generate airway and alveolar cells from iPS cells, aiming for clinical applications. The shortage of donors for lung transplantation is a serious problem worldwide. Taking advantage of the fact that iPS cells can provide as many lung cells as needed, the lab seeks to turn this into technologies useful for diagnosis and treatment.
Yoshinori Yoshida, Associate Professor
0 student voices
The Yoshida Lab uses iPS cell technology to conduct research on regenerative medicine and drug discovery for the heart. Its work ranges widely from basic research at the molecular level to translational research with clinical application in view.
Makoto Ikeya, Associate Professor
0 student voices
To use iPS cells in medicine, whether for cell transplantation, elucidating diseases, or drug discovery, it is essential to have methods for producing the target cells reliably and easily. The Ikeya Lab develops methods for inducing differentiation of cells that are difficult to make or for which simpler, more efficient methods are needed. In particular, it focuses on cells at intermediate stages of development, and develops methods that mimic the environment in the body to induce the target cells step by step, as well as culture methods that maintain the cells at each stage as stem cells. Using these technologies, the lab aims to develop new treatments for intractable diseases.
Hidetoshi Sakurai, Associate Professor
0 student voices
The Sakurai Lab aims to establish treatments for intractable muscle diseases, especially muscular dystrophy. There are two routes to treatment: cell transplantation therapy using progenitor cells made from iPS cells, and drug development that recreates the disease in vitro using patients' iPS cells.
Sayako Katada, Associate Professor
0 student voices
The Katada Lab studies how the fate of neural stem cells is determined and the diverse functions of the choroid plexus, which produces cerebrospinal fluid, aiming to understand everything from brain development to neurological diseases. The choroid plexus secretes various factors into cerebrospinal fluid and is involved in the development and maintenance of the brain. It also serves as a barrier between the blood and cerebrospinal fluid, mediating the exchange of information between the body and the brain, but much of its function remains unknown. In addition to basic research using mice, the lab creates cerebral cortex and choroid plexus organoids from the iPS cells of patients with neurological diseases and analyzes them.
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