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Saito Lab
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The lab recreates rare intractable diseases of childhood with patients' iPS cells to explore new treatments.
AboutAbout the lab
To diagnose and treat as many patients as possible.
The Saito Lab uses disease-specific iPS cells made from the cells of patients with rare, hard-to-treat diseases to analyze disease mechanisms and develop treatments.
Many rare intractable diseases that begin in childhood have unknown causes and no known treatments, and the suffering can last a lifetime. For diseases that cannot be studied adequately in mice or cultured cells, using patients' iPS cells is effective.
The lab mainly targets immune diseases (immunodeficiencies and autoinflammatory syndromes), blood diseases (such as bone marrow failure), and neuromuscular diseases (spinal muscular atrophy).
Key terms
- Disease-specific iPS cells
- iPS cells made from the cells of patients with a disease. They can recreate the disease state in a culture dish
- Autoinflammatory syndrome
- A disease with recurrent fever and inflammation without a trigger such as infection
- Hematopoietic stem cell
- A stem cell that gives rise to all types of blood cells
ResearchResearch themes
The lab uses iPS cells to study how interactions among various cells, such as immune cells and neurons, or blood cells and their surrounding cells, affect disease.
*Illustrative imageAnalyzing disease mechanisms with disease-specific iPS cells
The lab makes iPS cells from patients and develops systems to differentiate them. Using this technology, it collaborates with many researchers to create models of rare intractable diseases and analyze their mechanisms.
*Illustrative imageA gene essential for blood cell differentiation
By examining the function of a general transcription factor in hematopoietic stem and progenitor cells from human cord blood, the lab found that it plays a role in the differentiation of specific lineages, such as red blood cells and natural killer cells.
MembersFaculty
- ProfessorJun Saito
- Program-Specific Lecturer (Research Base)Akira Niwa
- Program-Specific Assistant Professor (Research Base)Yohko Kitagawa
- Assistant ProfessorYoko Nishinaka-Arai-Arai
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Stem Cell Research” The U.S. Food and Drug Administration / Public domain (cropped)
- Analyzing disease mechanisms with disease-specific iPS cells: “Fuentes de precursores hematopoyéticos” Diego Castro / CC BY-SA 4.0 (cropped)
- A gene essential for blood cell differentiation: “Red Blood Cells observed with scanning electron microscope (SEM). Left spherocyte. Right normal red blood cell” Joan-Lluis Vives-Corrons, Elena Krishnevskaya / CC BY 4.0 (cropped)
- Related lab (池谷研究室): “Migration of Neural Crest Cells (v2)” MWatson12 / CC BY-SA 4.0 (cropped)
- Related lab (堀田研究室): “Cas9 5AXW” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (櫻井研究室): “Skeletal muscle1-es” The original uploader was Jeremykemp at English Wikipedia. / CC BY 4.0 (cropped)
- Related lab (長船研究室): “Kidney Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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