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Sakurai Lab
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The lab uses iPS cells to pursue both cell transplantation and drug development for muscular dystrophy.
AboutAbout the lab
Treating muscular dystrophy with transplantation and drugs.
The Sakurai Lab aims to establish treatments for intractable muscle diseases, especially muscular dystrophy.
There are two routes to treatment: cell transplantation therapy using progenitor cells made from iPS cells, and drug development that recreates the disease in vitro using patients' iPS cells.
Key terms
- Skeletal muscle stem cells
- Stem cells found in muscle that rebuild damaged muscle fibers
- Satellite cells
- Skeletal muscle stem cells located next to muscle fibers
- iPS cell stock
- iPS cells prepared in advance with matched immune types for use in regenerative medicine
- Machine learning
- A technology that lets computers learn rules and patterns from data
ResearchResearch themes
The lab conducts research on cell transplantation therapy and on drug discovery using disease models.
*Illustrative imageCell transplantation for muscular dystrophy
The lab transplants skeletal muscle stem cells made from an iPS cell stock, aiming for regeneration of damaged muscle fibers and for the cells to engraft in the body as satellite cells. It has also succeeded in using machine learning to predict the future yield of skeletal muscle stem cells.
*Illustrative imageRecreating muscle diseases in a dish
In collaboration with pediatrics and neurology, the lab generates mature skeletal muscle from patients' iPS cells and builds models that reproduce the pathology of muscular dystrophy.
MembersFaculty
- Associate ProfessorHidetoshi Sakurai
- Program-Specific Assistant Professor (Research Base)Tomoya Uchimura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Skeletal muscle1-es” The original uploader was Jeremykemp at English Wikipedia. / CC BY 4.0 (cropped)
- Cell transplantation for muscular dystrophy: “Multinuclear muscle fiber cells and some associated mononuclear cells” MethylC5 / CC BY-SA 4.0 (cropped)
- Recreating muscle diseases in a dish: “Schematic of satellite cell myogenesis and markers typical of each stage” Zammit PS, Partridge TA, Yablonka-Reuveni Z. / CC BY-SA 4.0 (cropped)
- Related lab (堀田研究室): “Cas9 5AXW” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (吉田研究室): “Anatomy Heart Latin Tiesworks” Tvanbr / Public domain (cropped)
- Related lab (池谷研究室): “Migration of Neural Crest Cells (v2)” MWatson12 / CC BY-SA 4.0 (cropped)
- Related lab (長船研究室): “Kidney Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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