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Gotoh Lab
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The lab creates airway and alveolar cells from iPS cells to tackle the mechanisms and regeneration of intractable respiratory diseases.
AboutAbout the lab
Understanding and regenerating the respiratory system with iPS cells
The respiratory system is divided into two regions: the airways and the alveoli. The airways perform mucociliary clearance, which removes foreign particles and pathogens, while the alveoli perform gas exchange of oxygen and carbon dioxide.
The Gotoh Lab develops technologies to generate airway and alveolar cells from iPS cells, aiming for clinical applications.
The shortage of donors for lung transplantation is a serious problem worldwide. Taking advantage of the fact that iPS cells can provide as many lung cells as needed, the lab seeks to turn this into technologies useful for diagnosis and treatment.
Key terms
- Alveoli
- Tiny sacs deep in the lungs where oxygen and carbon dioxide are exchanged
- Mucociliary clearance
- A mechanism in which fine hairs (cilia) on airway cells move mucus to carry foreign particles and pathogens out of the airways
- Pulmonary fibrosis
- A disease in which the lungs become stiff, making it difficult to take in oxygen
- Primary ciliary dyskinesia
- A hereditary disease in which the cilia in the airways and elsewhere do not move properly, causing repeated infections
ResearchResearch themes
The lab works on two goals: reproducing intractable respiratory diseases in culture dishes to understand their mechanisms, and developing technologies to regenerate damaged lungs.
*Illustrative imageModeling intractable respiratory diseases in a culture dish
By improving the technology for generating lung cells from iPS cells, the lab has reported new disease models of pulmonary fibrosis and primary ciliary dyskinesia.
*Illustrative imageRestoring lung function
The lab is working to develop technologies that restore the function of damaged lungs using cells derived from human iPS cells.
MembersFaculty
- ProfessorShimpei Gotoh
- Program-Specific Assistant Professor (Research Base)Satoshi Konishi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bronchial anatomy” Patrick J. Lynch, medical illustrator / CC BY 2.5 (cropped)
- Modeling intractable respiratory diseases in a culture dish: “Influenza A virions on cilia human nasal epithelium SEM high magnification” Phage1990 / CC BY 4.0 (cropped)
- Restoring lung function: “Illustration of lungs and other visual elements related to asthma research - 1” NIAID / CC BY 2.0 (cropped)
- Related lab (堀田研究室): “Cas9 5AXW” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (金子研究室): “Human Natural Killer Cell ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (齋藤研究室): “Stem Cell Research” The U.S. Food and Drug Administration / Public domain (cropped)
- Related lab (吉田研究室): “Anatomy Heart Latin Tiesworks” Tvanbr / Public domain (cropped)
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