LAB LOGA page on LabLog, a review site (not the lab's official page)
Ikeya Lab
Machine-translated · View original
The lab recreates the developmental pathway to make the cells that give rise to bone and cartilage from iPS cells.
AboutAbout the lab
Generating cells by mimicking development.
To use iPS cells in medicine, whether for cell transplantation, elucidating diseases, or drug discovery, it is essential to have methods for producing the target cells reliably and easily.
The Ikeya Lab develops methods for inducing differentiation of cells that are difficult to make or for which simpler, more efficient methods are needed. In particular, it focuses on cells at intermediate stages of development, and develops methods that mimic the environment in the body to induce the target cells step by step, as well as culture methods that maintain the cells at each stage as stem cells.
Using these technologies, the lab aims to develop new treatments for intractable diseases.
Key terms
- Neural crest cells
- Cells that arise early in development and become a variety of tissues, such as facial bones and nerves
- Mesenchymal stem cells
- Stem cells that can become bone, cartilage, fat, and other tissues
- Organoid
- A small, organ-like tissue made by culturing stem cells and other cells in three dimensions
- Fibrodysplasia ossificans progressiva
- A rare genetic disease in which bone forms inside muscle and other tissues
ResearchResearch themes
The lab focuses on neural crest cells, somitic mesoderm, lateral plate mesoderm, and mesenchymal stem cells, conducting research from basic science to applications.
*Illustrative imageMaking jawbone from iPS cells
The jawbone develops from neural crest cells. The lab has succeeded in creating three-dimensional jawbone organoids from human iPS cells by following the developmental process of the jawbone.
*Illustrative imageMesenchymal cells change depending on their developmental path
The lab generated mesenchymal cells from iPS cells through five different developmental pathways and compared them, finding that the cells have distinct characteristics depending on the pathway.
*Illustrative imageAn intractable disease in which bone forms in muscle
The lab studies fibrodysplasia ossificans progressiva, a rare intractable disease in which bone forms within muscle.
MembersFaculty
- Associate ProfessorMakoto Ikeya
- Program-Specific Assistant ProfessorYayoi Toyooka
- Specially Appointed Assistant ProfessorSota Motoike
VoicesStudent voices
Ratings and reviews reflect the experiences of individual current or former students, not the lab's official views. Whether a lab has reviews, or how many, says nothing about the lab itself.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
Student ratings (0 students)
--
--
--
--
--
--
Student voices answer questions like these
- What's great about this lab?
- What did you learn after joining?
- What's the vibe, and what is the professor like?
- Who is this lab for?
- Where do graduates go?
Your experience can help younger students choose their lab. Your name won't be shown.
Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Ikeya Lab
Hotta LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationMore than half of intractable diseases that are difficult to…
Saito LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationDisease modeling and therapy development for rare intractabl…
Kaneko LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationImmune regenerative therapy using the properties of iPS cell…
Sakurai LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationTreatment of intractable muscle diseases, especially muscula…The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Migration of Neural Crest Cells (v2)” MWatson12 / CC BY-SA 4.0 (cropped)
- Making jawbone from iPS cells: “Gray995 zh” Henry Vandyke Carter / Public domain (cropped)
- Mesenchymal cells change depending on their developmental path: “Placenta mesenchymal stromal cells mechanisms of action” de la Torre, P., Jesús Pérez-Lorenzo, M., & I. Flores, A / CC BY 4.0 (cropped)
- An intractable disease in which bone forms in muscle: “Bone-cross-section” Baedr-9439 / CC0 (cropped)
- Related lab (Hotta Lab): “Cas9 5AXW” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (Saito Lab): “Stem Cell Research” The U.S. Food and Drug Administration / Public domain (cropped)
- Related lab (Kaneko Lab): “Human Natural Killer Cell ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Sakurai Lab): “Skeletal muscle1-es” The original uploader was Jeremykemp at English Wikipedia. / CC BY 4.0 (cropped)
About LabLog
LabLog is a lab review app for students only. Student members at each university interview students in labs and publish what they say. Student voices can only be read by students who sign up with a university email address. Operated by bestiee Inc.
Learn more about LabLog ↗Search engines and AI may reference the basic lab info and rating summaries on this page and the description of LabLog. Student voices are for student members only. Automated collection by programs (scraping, or input to or training of AI) is prohibited under Article 8 of the Terms of Service. If you need data for research or analysis, please contact us.