LAB LOGA page on LabLog, a review site (not the lab's official page)
Inoue Lab
Machine-translated · View original
The lab uses patients' iPS cells to recreate intractable neurological diseases in the dish and bring therapeutic drugs to the clinic.
AboutAbout the lab
From the culture dish to the clinical trial, and from the clinical trial back to the culture dish.
With the arrival of a super-aged society, the number of patients with intractable neurological diseases and dementia is growing. For intractable neurological diseases such as ALS and Alzheimer's disease, there are still no fundamental treatments that completely halt progression.
The Inoue Lab aims to establish fundamental treatments for intractable neurological diseases by using patients' iPS cells in both directions: from research on disease mechanisms and therapies to clinical trials, and from clinical trials back to that research.
Key terms
- ALS
- Amyotrophic lateral sclerosis. A disease in which motor neurons are gradually lost and muscles stop moving
- Investigator-initiated clinical trial
- A clinical trial planned and conducted by physicians themselves, rather than by a pharmaceutical company
- Frontotemporal lobar degeneration
- A disease that causes changes in personality and behavior and language impairment. It is one of the main causes of young-onset dementia
- Microglia
- Glial cells that play an immune role in the brain
ResearchResearch themes
The lab models diseases with patients' iPS cells, identifies drug candidates, and takes them on to clinical trials.
*Illustrative imageTaking an Alzheimer's disease drug into a clinical trial
In a "clinical trial in a dish," the lab found that the existing drug bromocriptine strongly suppresses the production of amyloid-β. Its safety and efficacy were evaluated in an investigator-initiated clinical trial.
*Illustrative imageTherapeutic targets in frontotemporal lobar degeneration
Using iPS cells from patients with the type of frontotemporal lobar degeneration in which tau protein accumulates, the lab found that abnormal tau builds up in neurons and makes them prone to cell death.
*Illustrative imageNeurological disease seen through glial cells
The lab studies glial cells involved in ALS and Alzheimer's disease. It has shown that the APOE gene regulates the self-renewal of microglia.
MembersFaculty
- ProfessorHaruhisa Inoue
- Program-Specific Associate Professor (Research Base)Keiko Imamura
- Specially Appointed Associate ProfessorHaruhiko Banno
- Program-Specific Lecturer (Research Base)Takayuki Kondo
- Program-Specific Assistant ProfessorTaro Okunomiya
VoicesStudent voices
Ratings and reviews reflect the experiences of individual current or former students, not the lab's official views. Whether a lab has reviews, or how many, says nothing about the lab itself.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
Student ratings (0 students)
--
--
--
--
--
--
Student voices answer questions like these
- What's great about this lab?
- What did you learn after joining?
- What's the vibe, and what is the professor like?
- Who is this lab for?
- Where do graduates go?
Your experience can help younger students choose their lab. Your name won't be shown.
Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Inoue Lab
Osafune LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationIntractable kidney, pancreatic and liver diseases such as ch…
Hotta LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationMore than half of intractable diseases that are difficult to…
Katada LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationFate determination of neural stem cells and functions of the…
Sakurai LabCenter for iPS Cell Research and Application, Department of Clinical ApplicationTreatment of intractable muscle diseases, especially muscula…The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Rat primary cortical neuron culture, deconvolved z-stack overlay ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Taking an Alzheimer's disease drug into a clinical trial: “Alzheimers Disease” BruceBlaus / CC BY-SA 4.0 (cropped)
- Therapeutic targets in frontotemporal lobar degeneration: “Oligodendrocytes and tau protein neurofibrillary tangles” Guo, S.; Yu, X.; Zhang, H. / CC BY 4.0 (cropped)
- Neurological disease seen through glial cells: “Nervous system - Microglia 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Osafune Lab): “Kidney Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Hotta Lab): “Cas9 5AXW” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (Katada Lab): “Blausen 0216 CerebrospinalSystem” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Related lab (Sakurai Lab): “Skeletal muscle1-es” The original uploader was Jeremykemp at English Wikipedia. / CC BY 4.0 (cropped)
About LabLog
LabLog is a lab review app for students only. Student members at each university interview students in labs and publish what they say. Student voices can only be read by students who sign up with a university email address. Operated by bestiee Inc.
Learn more about LabLog ↗Search engines and AI may reference the basic lab info and rating summaries on this page and the description of LabLog. Student voices are for student members only. Automated collection by programs (scraping, or input to or training of AI) is prohibited under Article 8 of the Terms of Service. If you need data for research or analysis, please contact us.