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Kaneko Lab
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The lab creates rejuvenated immune cells from iPS cells to develop new treatments for cancer and other diseases.
AboutAbout the lab
Rebuilding immunity with iPS cells.
The Kaneko Lab conducts research toward immune regenerative therapy that takes advantage of the properties of iPS cells.
iPS cells made from T cells retain the receptor gene sequences of the original T cell. Using this feature, the lab established a method to produce large numbers of rejuvenated T cells that recognize a targeted antigen.
The lab aims to contribute to the realization of regenerative medicine and to better treatment outcomes in cancer, infectious diseases, autoimmune diseases, and transplantation medicine.
Key terms
- T cell
- A lymphocyte that recognizes specific markers (antigens) and attacks abnormal cells
- CAR
- A receptor artificially engineered to recognize cancer markers. It is introduced into T cells and other cells so that they attack cancer
- NK cell
- An innate immune lymphocyte that rapidly attacks abnormal cells
- HLA
- A marker on the cell surface that distinguishes self from non-self. It is involved in transplant rejection
ResearchResearch themes
The lab is advancing the clinical development of cancer therapy using killer lymphocytes made from iPS cells, along with basic research on how to generate immune cells.
*Illustrative imageTreating cancer with iPS cell-derived killer lymphocytes
The lab is pursuing three clinical developments, including the treatment of ovarian cancer with regenerated innate killer lymphocytes carrying a CAR that recognizes cancer markers.
*Illustrative imageT cells usable for many patients
The lab has shown that introducing a disease-specific receptor gene into iPS cells from an HLA-matched donor can produce T cells that can be used for multiple patients. It is also developing methods to reduce the immunogenicity of iPS cells.
*Illustrative imageDiverse immune cells from iPS cells
The lab differentiates various T cell types such as helper T cells and NKT cells, innate lymphoid cells including NK cells, and macrophages from iPS cells, and is developing immune regenerative therapies that make use of the characteristics of each.
MembersFaculty
- ProfessorShin Kaneko
- Program-Specific Lecturer (Research Base)Shoichi Iriguchi
- Program-Specific Assistant Professor (Research Base)Bo Wang
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human Natural Killer Cell ( )” NIAID / CC BY 2.0 (cropped)
- Treating cancer with iPS cell-derived killer lymphocytes: “063-T-CellReceptor-MHC” David Goodsell / CC BY 3.0 (cropped)
- T cells usable for many patients: “Macrophage (NIH BioArt 309)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Diverse immune cells from iPS cells: “Leukocyt” Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick) / Public domain (cropped)
- Related lab (Ikeya Lab): “Migration of Neural Crest Cells (v2)” MWatson12 / CC BY-SA 4.0 (cropped)
- Related lab (Yoshida Lab): “Anatomy Heart Latin Tiesworks” Tvanbr / Public domain (cropped)
- Related lab (Sakurai Lab): “Skeletal muscle1-es” The original uploader was Jeremykemp at English Wikipedia. / CC BY 4.0 (cropped)
- Related lab (Gotoh Lab): “Bronchial anatomy” Patrick J. Lynch, medical illustrator / CC BY 2.5 (cropped)
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