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Katada Lab
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The lab explores brain development and neurological diseases through the choroid plexus, which produces cerebrospinal fluid.

AboutAbout the lab
Focusing on the choroid plexus, which nurtures and protects the brain.
The Katada Lab studies how the fate of neural stem cells is determined and the diverse functions of the choroid plexus, which produces cerebrospinal fluid, aiming to understand everything from brain development to neurological diseases.
The choroid plexus secretes various factors into cerebrospinal fluid and is involved in the development and maintenance of the brain. It also serves as a barrier between the blood and cerebrospinal fluid, mediating the exchange of information between the body and the brain, but much of its function remains unknown.
In addition to basic research using mice, the lab creates cerebral cortex and choroid plexus organoids from the iPS cells of patients with neurological diseases and analyzes them.
Key terms
- Choroid plexus
- Tissue in the brain that produces cerebrospinal fluid
- Neural stem cells
- Stem cells that give rise to neurons and glial cells
- Epigenome
- Chemical marks that switch gene activity on and off without changing the DNA sequence
- Assembloid
- A combination of separately made organoids that recreates the connections between organs
ResearchResearch themes
The lab aims to open up the possibility of new treatments that target the choroid plexus.
*Illustrative imageHow neural stem cells determine their fate
Neural stem cells integrate information about developmental timing and their surrounding environment, and determine their fate by altering their own epigenome.
*Illustrative imageChoroid plexus secreted factors and disease
The lab found that age-related changes in the choroid plexus affect memory and learning. It is building experimental systems to examine changes in the choroid plexus in neurodevelopmental disorders and neurodegenerative diseases.
*Illustrative imageAssembloids of the cerebral cortex and choroid plexus
Using assembloids that fuse cerebral cortex and choroid plexus organoids made from patients' iPS cells, the lab examines how the choroid plexus affects the development and function of the cortex.
MembersFaculty
- Associate ProfessorSayako Katada
- Program-Specific Assistant Professor (Research Base)Emi Yamasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blausen 0216 CerebrospinalSystem” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- How neural stem cells determine their fate: “BrdU staining (green) of radial glia” Jason Snyder / CC BY 2.0 (cropped)
- Choroid plexus secreted factors and disease: “CSF circulation” Mark D. Shen / CC BY 4.0 (cropped)
- Assembloids of the cerebral cortex and choroid plexus: “Querschnitt Gehirnmodell small” Madeline Lancaster / IMBA / CC BY-SA 4.0 (cropped)
- Related lab (吉田研究室): “Anatomy Heart Latin Tiesworks” Tvanbr / Public domain (cropped)
- Related lab (池谷研究室): “Migration of Neural Crest Cells (v2)” MWatson12 / CC BY-SA 4.0 (cropped)
- Related lab (井上研究室): “Rat primary cortical neuron culture, deconvolved z-stack overlay ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Related lab (長船研究室): “Kidney Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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