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30 labs · 0 student voices
Faculties at Kyushu University ›
Shigehiro Odo, Professor Emeritus (Specially Commissioned Professor)
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The Pharmacokinetics Lab studies how molecules such as drugs, proteins, and microRNAs move within the body, with the aim of contributing to clinical pharmaceutical sciences. Its research spans physiology, pharmacology, pharmaceutics, and structural biology, and covers topics such as organ–cell crosstalk, kidney and liver injury, cancer, and the circadian clock. The lab also works on developing lipid nanoparticles (LNPs) for use in vaccine formulations and other applications, determining protein structures by cryo-electron microscopy, and developing medical devices. On the lab's website, it is introduced as the "Naoya Matsunaga Lab."
Satoru Koyanagi, Professor
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The Pharmaceutics Lab focuses on the fact that the effects and side effects of drugs change depending on the time of day they are taken, and studies how drugs should be used. The circadian rhythm, the roughly 24-hour cycle of bodily functions, is controlled by a group of genes called "clock genes." Clock genes are also thought to control the rhythm of the time of day when disease symptoms get worse, but the mechanisms are still largely unknown. By understanding both the time-of-day variation in drug effects and side effects and the rhythms of disease, the lab aims to contribute to chronopharmacotherapy, which sets the optimal timing of drug administration.
Daisuke Kobayashi, Associate Professor
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The Clinical Drug Optimization Lab studies leftover medications, drug concentrations in the blood, side effects of anticancer drugs, and muscle wasting. Working with local community pharmacies, the lab collects information on leftover medications and examines the characteristics of patients who are not taking their medications properly. For side effects of anticancer drugs and sarcopenia in cancer patients, the lab searches for countermeasures and therapeutic drugs through both basic and clinical research.
Makoto Tsuda, Professor
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The lab studies how pain and itch are sensed and transmitted, and how those mechanisms break down and lead to chronic sensory abnormalities. A distinctive feature is its focus not only on neurons but also on the surrounding glial cells (microglia and astrocytes). Combining techniques from genetic engineering, in vivo imaging, electrophysiology, optogenetics, and behavioral pharmacology, the lab investigates these mechanisms from molecules to cells to whole animals. It aims to find drug discovery targets that could change how pain and itch are treated, and to contribute to creating new drugs through collaborative research among industry, academia, and government.
Motohiro Nishida, Professor
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The lab aims to create strategies that contribute to human healthy longevity, based on research into redox and energy metabolism in the heart. Focusing on proteins that cause muscle diseases such as heart failure and muscle-wasting diseases, the lab investigates how muscle adapts to external stress from the perspective of quality control of intracellular proteins and organelles (mainly mitochondria). In close collaboration with the Division of Cardiocirculatory Signaling at the National Institute for Physiological Sciences, the lab also works on expanding the indications of approved drugs and on developing new drugs based on those compounds.
Katsumi Maenaka, Professor
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The lab works on identifying disease-specific molecules using clinical specimens and analyzing the functions of those molecules. Its research also focuses on molecular design for drug discovery, developing platforms for converting large molecules into small molecules, and research support toward practical application. Kyushu University's researcher information lists Prof. Maenaka's research theme as "protein science research related to immune and infectious diseases." Prof. Maenaka also holds a concurrent appointment at the Faculty of Pharmaceutical Sciences, Hokkaido University.
Yuta Kohro, Associate Professor
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The lab of Associate Professor Yuta Kohro focuses on the diversity of glial cells in the spinal cord and studies how sensory information is transmitted. In particular, it investigates the roles of astrocyte subpopulations in the spinal dorsal horn and the roles of spinal glia in neuropathic pain. Recently, the lab has also been working to elucidate how the whole body is regulated through body fluids such as blood and cerebrospinal fluid, and the mechanisms of disease.
Caaveiro Jose, Professor
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The Protein Drug Discovery Lab studies interactions between biomolecules, with the aim of understanding and controlling proteins involved in disease. Using advanced measurement techniques, the lab examines interactions involved in cancer, inflammatory diseases, infectious diseases, and more. It develops small molecules, peptides, and antibodies that can control these interactions, and also aims to design new drug modalities using protein engineering. Structural analysis, which determines the structures of target proteins by NMR, X-ray crystallography, and cryo-electron microscopy, is the central pillar of the lab's research.
Tsutomu Tsutomu, Professor
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The Molecular Biology Lab studies how replication of genomic DNA begins and how it is regulated when cells proliferate. Genome replication occurs only once per cell cycle, which precisely doubles the genetic information. Using Escherichia coli as a model, the lab investigates the mechanisms that maintain this once-only replication. It combines approaches from molecular genetics, biochemistry, molecular biology, and cell biology in its research.
Yuji Ishii, Professor
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The Cellular Biopharmacy Lab studies, at the molecular level, how foreign toxic chemicals harm the body and how the body responds in trying to eliminate them. The lab belongs to public health pharmaceutical sciences (eisei yakugaku), the science of keeping healthy people from becoming ill. This field examines the toxicity of external factors that damage health and the ways to eliminate them. Using laboratory animals, the lab investigates how dioxin affects the health of the next generation and the mother's ability to care for her offspring. The lab also studies drug metabolism and the functions of lysosomes.
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