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Clinical Drug Optimization Lab
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A lab that investigates patients' medication use and side effects from both clinical and basic research perspectives.
AboutAbout the lab
Getting the most out of every drug, without waste.
The Clinical Drug Optimization Lab studies leftover medications, drug concentrations in the blood, side effects of anticancer drugs, and muscle wasting.
Working with local community pharmacies, the lab collects information on leftover medications and examines the characteristics of patients who are not taking their medications properly.
For side effects of anticancer drugs and sarcopenia in cancer patients, the lab searches for countermeasures and therapeutic drugs through both basic and clinical research.
Key terms
- Medication adherence
- The degree to which patients keep taking prescribed drugs as instructed
- TDM
- Therapeutic drug monitoring: a method of measuring the concentration of a drug in the blood and deciding the dose based on the result
- Sarcopenia
- A condition in which muscles throughout the body waste away and interfere with daily life
- Drug repositioning
- A method of searching among already-approved drugs for ones that are effective against a different disease
ResearchResearch themes
The lab aims to make prescribed drugs work to their fullest without waste, and to realize safe anticancer drug treatment with few adverse events. Its work includes surveys conducted with community pharmacies, measurement of blood concentrations of antiepileptic drugs, and basic and clinical research on the side effects of anticancer drugs and on sarcopenia.
*Illustrative imageFactors behind poor medication use, explored through leftover medications
Working with local community pharmacies, the lab collects information on leftover medications and examines the characteristics of patients thought to have poor medication adherence, as well as the characteristics of prescriptions and drugs. By identifying the factors, it aims to lead to clinical application and interventions.
*Illustrative imageTDM of new antiepileptic drugs
For new antiepileptic drugs such as perampanel and lacosamide, measurement methods for TDM have not been sufficiently established at medical facilities. The lab establishes a method to measure them simultaneously by high-performance liquid chromatography–mass spectrometry, and analyzes patients' blood concentrations in relation to efficacy and adverse events.
*Illustrative imageCountermeasures for side effects of anticancer drugs
No effective countermeasures have yet been established for peripheral neuropathy (such as numbness in the hands and feet) caused by platinum-based and taxane anticancer drugs, or for hand-foot syndrome caused by capecitabine. The lab explores the mechanisms behind these side effects and countermeasures through both basic and clinical research.
*Illustrative imageDrug repositioning for sarcopenia
Sarcopenia is a condition in which muscles throughout the body waste away and interfere with daily life, and in cancer patients it also affects prognosis. Through both basic and clinical research, the lab investigates its mechanisms and searches among already-approved drugs for effective ones, aiming for clinical application.
MembersFaculty
The members of the Clinical Drug Optimization Lab consist of faculty members and undergraduate students.As of 2026
- Associate ProfessorDaisuke Kobayashi
- Assistant ProfessorShunsuke Fujita
- Assistant ProfessorTakashi Ogino
- Assistant ProfessorRyosuke Matsukane
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pharmacie in Paulista Avenue” Wilfredor / CC BY-SA 4.0 (cropped)
- Factors behind poor medication use, explored through leftover medications: “2023 Kasetka z lekami” Jacek Halicki / CC BY-SA 4.0 (cropped)
- TDM of new antiepileptic drugs: “Testing Blood Sugar Levels” Reversing Your Diabetes Today / CC0 (cropped)
- Countermeasures for side effects of anticancer drugs: “Gold Nanoparticles' aggregation” Nadiia Honcharenko / CC BY 4.0 (cropped)
- Drug repositioning for sarcopenia: “1025 Atrophy” OpenStax / CC BY 4.0 (cropped)
- Related lab (臨床薬物治療学分野
（協力講座） ): “Bio-inspired hybrid multifunctional drug delivery system (cropped)” Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic and Fabio Zobi / CC BY-SA 4.0 (cropped) - Related lab (情報解析薬学講座
（協力講座） ): “Old pharmacy pills exposition in exposition History of pharmacies in Kuks Hospital in Kuks, Trutnov District” Jiří Sedláček / CC BY-SA 4.0 (cropped) - Related lab (薬剤学分野): “Biological clock human-no” User:Soulkeeper / CC BY-SA 3.0 (cropped)
- Related lab (薬物送達システム学分野
（連携講座） ): “A person having two capsules at home” Curpharar / CC BY-SA 4.0 (cropped)
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