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Pharmaceutics Lab
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A pharmaceutics lab that explores the best time of day for drugs to work, starting from clock genes.
AboutAbout the lab
Finding the best time for a drug to work, through clock genes.
The Pharmaceutics Lab focuses on the fact that the effects and side effects of drugs change depending on the time of day they are taken, and studies how drugs should be used.
The circadian rhythm, the roughly 24-hour cycle of bodily functions, is controlled by a group of genes called "clock genes."
Clock genes are also thought to control the rhythm of the time of day when disease symptoms get worse, but the mechanisms are still largely unknown.
By understanding both the time-of-day variation in drug effects and side effects and the rhythms of disease, the lab aims to contribute to chronopharmacotherapy, which sets the optimal timing of drug administration.
Key terms
- Clock genes
- A group of genes that control the roughly 24-hour rhythm seen in the body's functions
- Circadian rhythm
- A rhythm with a 24-hour cycle seen in bodily functions, such as the sleep–wake cycle and hormone secretion
- Chronopharmacotherapy
- Treatment that sets the optimal timing of drug administration, based on the fact that the effects and side effects of drugs change depending on the time of day they are taken
- Immune checkpoint inhibitors
- Drugs used to treat lung cancer. It has become clear that their efficacy differs depending on the time of day they are administered
NewsLab news
Lecturer Akito Tsuruta received the 2026 Academic Encouragement Award of the Kyushu-Yamaguchi Branch of the Pharmaceutical Society of Japan
A doctoral student received an Excellent Presentation Award at the 20th Medical Pharmaceutical Science Symposium for Next-Generation Young Researchers
A paper on the mechanism by which the clock gene TIMELESS regulates stemness of glioblastoma cells was published in J Biol Chem
A new mechanism by which the circadian clock protein BMAL1 promotes inflammation was elucidated, published in Cell Reports
ResearchResearch themes
The lab focuses on the fact that the effects and side effects of drugs change depending on the time of day they are taken. Using the function of clock genes, which control the body's 24-hour rhythm, it analyzes the underlying mechanisms and works to establish optimal dosing methods. It also pays attention to the fact that disease symptoms and onset get worse at particular times of day, and aims to make drugs safer and easier to use by understanding both the time-of-day changes in how drugs work and the rhythms of disease.
*Illustrative imageDosing design for immune checkpoint inhibitors
This research designs the optimal way to administer immune checkpoint inhibitors, using as a clue the mechanism by which the immune response to cancer is controlled by the daily rhythm.
*Illustrative imageMolecular pathology and therapeutic targets of malignant glioma
For malignant glioma, the lab analyzes how the disease arises at the molecular level and searches for molecules that could serve as therapeutic targets.
*Illustrative imageMetabolic changes and therapeutic targets in liver cancer
Building on the molecular mechanisms of the circadian clock, the lab clarifies the mechanisms by which metabolism changes in liver cancer and searches for therapeutic targets.
*Illustrative imageChronopharmacotherapy with antibody-drug conjugates for breast cancer
For HER2-negative breast cancer, the lab is working to establish chronopharmacotherapy that takes into account the time of day at which antibody-drug conjugates are administered.
MembersFaculty
The members of the Pharmaceutics Lab consist of faculty members and doctoral, master's, and undergraduate students.As of 2026
- ProfessorSatoru Koyanagi
- LecturerAkito Tsuruta
- Assistant ProfessorTomoaki Yamauchi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Biological clock human-no” User:Soulkeeper / CC BY-SA 3.0 (cropped)
- Dosing design for immune checkpoint inhibitors: “Pendulum clock by Jacob Kock, antique furniture photography, IMG 0931 edit” Christoph Braun / CC0 (cropped)
- Molecular pathology and therapeutic targets of malignant glioma: “4-year-old-boy-with-angiocentric-glioma-Axial-T2weighted-image-shows-a-hyperintense” Manoj Kumar Raghu H Ramakrishnaiah Rohan Samant / CC BY-SA 4.0 (cropped)
- Metabolic changes and therapeutic targets in liver cancer: “Diagram showing stage 1 liver cancer CRUK 426 es” Cancer Research UK / CC BY-SA 4.0 (cropped)
- Chronopharmacotherapy with antibody-drug conjugates for breast cancer: “Antibody-drug conjugate” Bioconjugator / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacokinetics Lab): “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
- Related lab (Drug Delivery Systems Lab): “A person having two capsules at home” Curpharar / CC BY-SA 4.0 (cropped)
- Related lab (Clinical Pharmacotherapy Lab): “Bio-inspired hybrid multifunctional drug delivery system (cropped)” Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic and Fabio Zobi / CC BY-SA 4.0 (cropped)
- Related lab (Pharmaceutical Information Analysis Lab): “Old pharmacy pills exposition in exposition History of pharmacies in Kuks Hospital in Kuks, Trutnov District” Jiří Sedláček / CC BY-SA 4.0 (cropped)
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