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Molecular Biology Lab
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The lab uses Escherichia coli as a model to explore how genomic DNA replication works.
AboutAbout the lab
Using E. coli to uncover how genome replication works
The Molecular Biology Lab studies how replication of genomic DNA begins and how it is regulated when cells proliferate.
Genome replication occurs only once per cell cycle, which precisely doubles the genetic information.
Using Escherichia coli as a model, the lab investigates the mechanisms that maintain this once-only replication.
It combines approaches from molecular genetics, biochemistry, molecular biology, and cell biology in its research.
Key terms
- Genomic DNA replication
- The process by which a cell makes a copy of its genetic information and passes it on to daughter cells when it proliferates.
- DnaA
- A protein that plays the central role in the reaction that initiates chromosomal DNA replication in Escherichia coli.
- Cell cycle
- The sequence in which a cell proceeds in order through the steps of proliferation, such as genome replication and segregation, and cell division.
NewsLab news
A paper on the interaction between DnaA and DnaB has been accepted by Nucleic Acids Research
A paper on the helicase loader DciA has been accepted by the Journal of Biological Chemistry
A paper on the regulation of gene expression by DnaA has been accepted by Genes & Genetic Systems
A paper on PriC, which rescues stalled replication initiation, has been published in eLife
A paper on a new mechanism that regulates DARS2 has been published in Nucleic Acids Research
ResearchResearch themes
When cells proliferate, genomic DNA is replicated only once, precisely doubling the genetic information. Using Escherichia coli as a model, the lab investigates the mechanisms that maintain this once-only replication, centering on the DnaA protein, which is responsible for initiating replication.
*Illustrative imageMolecular mechanisms of replication initiation
The lab investigates the molecular mechanisms by which replication of genomic DNA begins. In particular, it seeks to clarify how the replication initiator protein functions and the mechanisms behind its activity.
*Illustrative imageMechanisms that regulate replication initiation
The lab investigates the molecular mechanisms that regulate the initiation of genomic DNA replication. In particular, it aims to clarify how the proteins involved in this regulation function and the mechanisms behind their activity.
*Illustrative imageMechanisms that regulate the cell cycle
The lab investigates genome functions involved in cell cycle regulation, including genome segregation, cell division, and the stress response. In particular, it works on discovering new functions and clarifying new interactions between genes.
*Illustrative imageBasic research for drugs that regulate replication
The lab also carries out basic research in drug discovery, aimed at developing drugs that regulate DNA replication.
MembersFaculty
- ProfessorTsutomu Tsutomu
- Associate ProfessorShogo Ozaki
- Assistant ProfessorKazutoshi Kasho
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blue-white test” Stefan Walkowski / CC BY-SA 4.0 (cropped)
- Molecular mechanisms of replication initiation: “Bidirectional DNA replication in Bacteria” Bootan68 / CC BY-SA 3.0 (cropped)
- Mechanisms that regulate replication initiation: “Bacterial colonies” Korinna / CC BY 4.0 (cropped)
- Mechanisms that regulate the cell cycle: “Cell cycle showing G0 G1 arrest” Lucia de Diego Mialdea / CC BY-SA 4.0 (cropped)
- Basic research for drugs that regulate replication: “Antibiotic sensitivity and resistance” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (医薬細胞生化学分野): “Células de cebolla aumento total 100X en división celular” BioGenZambrano / CC BY-SA 4.0 (cropped)
- Related lab (国際化学物理薬学分野): “Probable Nucleic Acid precipitated” michael / CC BY 2.0 (cropped)
- Related lab (薬物分子設計学分野): “Kandiszucker” Dietmar Rabich / CC BY-SA 4.0 (cropped)
- Related lab (薬物送達システム学分野
（連携講座） ): “A person having two capsules at home” Curpharar / CC BY-SA 4.0 (cropped)
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