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Pathophysiology Lab
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The lab studies how sensation and pain work, starting from glial cells in the spinal cord.
AboutAbout the lab
Exploring how sensory information is transmitted, through the diversity of glial cells
The lab of Associate Professor Yuta Kohro focuses on the diversity of glial cells in the spinal cord and studies how sensory information is transmitted.
In particular, it investigates the roles of astrocyte subpopulations in the spinal dorsal horn and the roles of spinal glia in neuropathic pain.
Recently, the lab has also been working to elucidate how the whole body is regulated through body fluids such as blood and cerebrospinal fluid, and the mechanisms of disease.
Key terms
- Astrocyte
- A type of glial cell. This lab focuses on the existence of subpopulations with different properties and studies their functions.
- Spinal dorsal horn
- The region on the dorsal (back) side of the spinal cord. It is the site where the lab studies the transmission of sensory information.
- Neuropathic pain
- Severe, chronic pain that arises after nerve damage.
ResearchResearch themes
Using the diversity of glial cells in the spinal cord as its starting point, the lab aims to clarify how sensory information is transmitted. It also studies how the whole body is regulated through blood and cerebrospinal fluid, and how diseases arise.
*Illustrative imageWhole-body regulation and disease mediated by body fluids
The lab investigates how pathways mediated by body fluids such as blood and cerebrospinal fluid are involved in whole-body regulation and in the mechanisms of disease.
*Illustrative imageAstrocyte subpopulations in the spinal dorsal horn
The lab focuses on the subpopulations seen among astrocytes in the spinal dorsal horn, and aims to clarify the function of each.
*Illustrative imageNeuropathic pain and spinal glia
The lab investigates what roles glial cells in the spinal dorsal horn play when neuropathic pain occurs.
MembersFaculty
- Associate ProfessorYuta Kohro
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Astrocyte (NIH BioArt )” NIH NIAID Alexander Stewart / Public domain (cropped)
- Whole-body regulation and disease mediated by body fluids: “Nervous system - Cerebrospinal fluid -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Astrocyte subpopulations in the spinal dorsal horn: “Spinal cord (26 2 16) Rat; cross-section” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
- Neuropathic pain and spinal glia: “Immunofluorescence image of distributions of MBP and S100 in sciatic nerve of rat” Valeriia Ustymenko / CC BY 4.0 (cropped)
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- Related lab (薬理学分野): “Glial cells in the mouse spinal cord” xtream1101 (archive user) / CC BY-SA 4.0 (cropped)
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