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Cellular Biopharmacy Lab
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A public health pharmaceutical sciences lab that studies, at the molecular level, how harmful chemicals affect the body and how the body works to eliminate them.
AboutAbout the lab
Uncovering toxic substances through the pharmaceutical science of protecting life.
The Cellular Biopharmacy Lab studies, at the molecular level, how foreign toxic chemicals harm the body and how the body responds in trying to eliminate them.
The lab belongs to public health pharmaceutical sciences (eisei yakugaku), the science of keeping healthy people from becoming ill. This field examines the toxicity of external factors that damage health and the ways to eliminate them.
Using laboratory animals, the lab investigates how dioxin affects the health of the next generation and the mother's ability to care for her offspring.
The lab also studies drug metabolism and the functions of lysosomes.
Key terms
- Public health pharmaceutical sciences (eisei yakugaku)
- A field of pharmaceutical science that studies the toxicity of external factors that harm health, and ways to eliminate them, so that healthy people do not become ill
- Dioxin
- An environmental pollutant. There is concern that it may harm human health through contaminated food
- Luteinizing hormone
- A type of hormone produced in the pituitary gland of the brain
- UGT
- UDP-glucuronosyltransferase. An enzyme involved in drug metabolism, in which foreign substances are chemically transformed in the body
NewsLab news
Student receives a Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
Yuji Ishii joins as Professor
Student receives a Best Poster Award at the Forum 2025 Japan/Korea Joint Symposium
Student receives a Student Excellent Presentation Award at the 145th Annual Meeting of the Pharmaceutical Society of Japan
Student receives a Best Poster Award at the Forum 2024 Japan/Korea Joint Symposium
ResearchResearch themes
The lab's goal is to understand at the molecular level why foreign toxic chemicals are harmful and how the body responds to eliminate that toxicity. Its topics include the effects of dioxin on the next generation, changes in the activity of drug-metabolizing enzymes, and the physiological functions of lysosomes.
*Illustrative imageEffects of dioxin on the next generation
The lab has shown that in pregnant rats given dioxin, production of luteinizing hormone in the fetus is impaired, and sexual immaturity persists after the offspring grow up. It also investigates the decline in maternal care by mother rats.
*Illustrative imageFactors that alter drug-metabolizing capacity
The lab has proposed its own hypothesis that the drug-metabolizing enzymes P450 and UGT associate with each other and alter each other's functions, and has presented examples supporting it. It has also found fatty acid derivatives and nucleotides that regulate the activity of UGT.
*Illustrative imageInduction of drug-metabolizing enzymes and illicit drugs
The lab also studies the mechanisms by which expression of drug-metabolizing enzymes increases (induction mechanisms), as well as the metabolism and analysis of illicit drugs.
*Illustrative imagePhysiological functions of lysosomes
The lab conducts research on the physiological functions of lysosomes, including autophagy and intracellular protein trafficking.
MembersFaculty
Members of the Cellular Biopharmacy Lab include faculty and students at the doctoral, master's, and undergraduate levels.As of 2026
- ProfessorYuji Ishii
- Assistant ProfessorYuko Hirota
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Environmental pollution Kaduna state” Verified legend / CC BY-SA 4.0 (cropped)
- Effects of dioxin on the next generation: “Air pollution3” Janak Bhatta / CC BY-SA 4.0 (cropped)
- Factors that alter drug-metabolizing capacity: “Cytochrome P450 Binding Site” Mcassford / CC0 (cropped)
- Induction of drug-metabolizing enzymes and illicit drugs: “Day 286 - Drug samples and equipment collected for forensic testing ( )” West Midlands Police from West Midlands, United Kingdom / CC BY-SA 2.0 (cropped)
- Physiological functions of lysosomes: “Ευκαρυωτικό κύτταρο (ζωϊκό)” Mediran / CC BY-SA 3.0 (cropped)
- Related lab (Pathophysiology Lab): “Astrocyte (NIH BioArt )” NIH NIAID Alexander Stewart / Public domain (cropped)
- Related lab (Molecular Pathology Analysis Lab): “Rust and dirt” Roger McLassus / CC BY-SA 3.0 (cropped)
- Related lab (Kampo Medicine and Pharmaceutical Sciences Lab): “Herbal medicine cabinet 2023” Athikhun.suw / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacokinetics Lab): “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
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