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30 labs · 0 student voices
Faculties at Kyushu University ›
Masatoshi Fujita, Professor
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The Pharmaceutical Cell Biochemistry Lab studies how the replication of chromosomal DNA is regulated within the cell cycle. The lab investigates the mechanism behind the idea that when this regulation breaks down, chromosomes become unstable, which can lead to carcinogenesis. Focusing on the differences between normal cells and cancer cells, the lab also works on developing molecularly targeted anticancer drugs. On its website, the lab invites anyone interested to visit the lab at any time.
Seiichi Sakamoto, Associate Professor
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The Pharmacognosy Lab conducts research on living plants and is distinctive in pursuing research that is close to biology. The lab studies allelopathy and its mechanism of action at the molecular level, and works on breeding methods for medicinal plants using plant cell and tissue culture, and on establishing analytical methods for secondary metabolites. Through this basic research, the lab plans to develop elite cultivars of medicinal plants. Lab members learn some of the following techniques and knowledge: cultivation and culture of medicinal plants, gene cloning, and antibody production.
Kota Mayanagi, Lecturer
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The Structural Analysis for Drug Discovery Lab studies the structures of biological supramolecules using electron microscopy, and searches for treatments for chronic pain and chronic itch. In structural analysis, the lab uses cryo-electron microscopy to examine the shapes of complexes in which DNA and proteins are bound together. In drug discovery, the lab analyzes the mechanisms that cause chronic pain and chronic itch, and searches for therapeutic drugs. The lab also works on green pharma research, which includes the search for treatments for pain and itch.
Ken-ichi Yamada, Professor
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The Molecular Pathology Analysis Lab focuses on lipid oxidation in its drug discovery research and its search for biomarkers. Lipid peroxides and their metabolites have been reported to act as causative molecules in various diseases and in inflammation. For example, peroxides have been reported to be involved in ferroptosis, a newly identified form of cell death, and complexes of lipid-derived aldehydes and proteins have been reported to be involved in the onset of angiogenesis and age-related macular degeneration. The lab first developed technologies for detecting oxidized lipids and for screening target molecules. Recently, it has built on these technologies to verify candidate compounds in animal models of disease and to elucidate disease mechanisms.
Kenji Hamase, Professor
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The Analytical Chemistry Lab develops analytical technologies that distinguish and measure the D- and L-forms of amino acids, and applies them to drug discovery and the early diagnosis of disease. The lab has also developed an analytical method for the trace amounts of D-amino acids that form inside proteins, and uses it in research on age-related diseases and anti-aging. It also develops reagents for analysis, materials for separation, and analytical instruments. Through industry-academia-government collaborative research, the lab also works on developing functional foods, beverages, and cosmetics.
Akio Ojida, Professor
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The Drug Discovery Chemical Biology Lab synthesizes functional molecules of its own design and applies them to the analysis and control of biomolecules. Combining chemical biology and medicinal chemistry, the lab studies covalent drugs, which form covalent bonds with proteins to inhibit their function. The lab is also developing a new type of fluorescent probe that can visualize metabolism inside cells. On the lab's website, it is presented under the name "Ojida Lab."
Takashi Ohshima, Professor
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The Environmentally Benign Medicinal Chemistry Lab studies "environmentally benign catalytic reactions" for supplying functional molecules such as pharmaceuticals in ways that are gentle on the global environment. Using the reactions it has developed as key steps, the lab also works on the efficient synthesis of bioactive natural products and pharmaceuticals. The research rests on two strengths: the synthesis of organic compounds and the synthesis of metal complexes. Based on green chemistry, the lab works to contribute to green drug discovery.
Go Hirai, Professor
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The Drug Molecular Design Lab (Hirai Lab) designs and synthesizes new bioactive molecules, starting from natural products, sugars, and lipids. Combining knowledge of organic chemistry and biology, the lab makes molecules with higher activity or new functions with its own hands and evaluates how they work. The lab also works on the synthesis and functional evaluation of "glycan mimetics," in which the oxygen in the bond linking sugars in a glycan is replaced with carbon.
Takashi Niwa, Professor
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The Precision Molecular Transformation Chemistry Lab develops new organic reactions to create functional molecules needed in drug discovery, medicine, and life sciences. The lab's work rests on two pillars: organic reaction chemistry that achieves entirely new transformations, and precise molecular modification techniques that use diverse external stimuli. Applying knowledge and experience in organometallic chemistry, photochemistry, medicinal chemistry, and computational chemistry, the lab collaborates with researchers across fields to tackle challenges. The lab was launched in April 2023 at the Faculty of Pharmaceutical Sciences, Kyushu University.
Mariko Aso, Associate Professor
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The International Chemical and Physical Pharmaceutical Sciences Lab (the Aso Lab) works on creating useful biomolecules by introducing new functions into biomolecules such as nucleic acids, peptides, and proteins. The lab designs and synthesizes small organic molecules that carry functions, introduces them into biomolecules, and uses the resulting molecules to investigate how biomolecules work. It also aims at applications in treating diseases and detecting disease states.
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