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Pharmacokinetics Lab
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A lab that analyzes the kinetics of various molecules in the body, aiming to contribute to clinical pharmaceutical sciences.
AboutAbout the lab
Analyzing the kinetics of diverse molecules to advance clinical pharmaceutical sciences.
The Pharmacokinetics Lab studies how molecules such as drugs, proteins, and microRNAs move within the body, with the aim of contributing to clinical pharmaceutical sciences.
Its research spans physiology, pharmacology, pharmaceutics, and structural biology, and covers topics such as organ–cell crosstalk, kidney and liver injury, cancer, and the circadian clock.
The lab also works on developing lipid nanoparticles (LNPs) for use in vaccine formulations and other applications, determining protein structures by cryo-electron microscopy, and developing medical devices.
On the lab's website, it is introduced as the "Naoya Matsunaga Lab."
Key terms
- Drug-metabolizing enzymes
- Enzymes that metabolize drugs. Gene mutations and variation in expression can cause differences in drug concentrations in the body and in how well a drug works
- Clock genes
- Molecules that control biological rhythms. They are involved in the circadian clock
- LNP
- A nanoparticle made of lipids (lipid nanoparticle). A technology used in RNA vaccine formulations
- Cryo-electron microscopy
- A technique in which biological samples are rapidly frozen and observed with an electron microscope. It is used for analyzing molecular structures of proteins and other samples
NewsLab news
A doctoral student received an Excellent Presentation Award at the 42nd Annual Meeting of the Japan Society of Drug Delivery System
A master's student received the SNPEE 2026 Encouragement Award at the 41st Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan
A master's student received a Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
A master's student received an Excellent Presentation Award at the 42nd Kyushu-Yamaguchi Branch Meeting of the Pharmaceutical Society of Japan
A doctoral student received an Excellent Presentation Award at the 19th Medical Pharmaceutical Science Symposium for Next-Generation Young Researchers
ResearchResearch themes
The lab pursues a wide range of research with the analysis of the kinetics of molecules such as drugs, proteins, and microRNAs as its starting point. Its goal is to contribute to clinical pharmaceutical sciences through the analysis of molecular kinetics.
*Illustrative imageCauses of individual differences in drug efficacy and side effects
For a variety of drugs, the lab analyzes how mutations in drug-metabolizing enzyme genes and intra-individual variation in their expression create individual differences, as well as differences depending on the time of dosing, in drug efficacy and side effects.
*Illustrative imageOrgan–cell crosstalk and analysis of disease mechanisms
The lab creates animal models of diseases with low treatment satisfaction, and searches for new disease-related molecules and candidate therapeutic compounds from the perspective of organ–cell crosstalk. Research on new treatments for chronic kidney disease is one example.
*Illustrative imageLipid nanoparticles for vaccine formulations and other uses
For LNPs used in RNA vaccine formulations, the lab makes LNPs using novel materials unique to Kyushu University and develops new vaccine formulations against infectious diseases. It also investigates their pharmacokinetics in the body and their application to cancer treatment.
*Illustrative imageMedical devices that manipulate biological functions
The lab has shown that weak electrical current stimulation from an external device changes the expression of some genes, including clock genes. It is studying how to apply existing medical devices for electrical therapy to the treatment of rhythm disorders, lifestyle-related diseases, and cancer, and how to use newly built stimulation devices in medicine and agriculture.
MembersFaculty
The members of the Naoya Matsunaga Lab consist of faculty members, JSPS Research Fellows, and doctoral, master's, and undergraduate students.As of 2026
- Professor Emeritus (Specially Commissioned Professor)Shigehiro Odo
- ProfessorNaoya Matsunaga
- LecturerKengo Hamamura
- Assistant ProfessorYuya Yoshida
- Assistant ProfessorTomohito Tanihara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
- Causes of individual differences in drug efficacy and side effects: “Medicine Drug Pills on Plate” epSos .de / CC BY 2.0 (cropped)
- Organ–cell crosstalk and analysis of disease mechanisms: “Hist.Technik (2)” Rollroboter / CC BY-SA 3.0 (cropped)
- Lipid nanoparticles for vaccine formulations and other uses: “Vaccines-09-00065-g001” Michael D. Buschmann, Manuel J. Carrasco, Suman Alishetty, Mikell Paige, Mohamad G. Alameh, and Drew Weissman / CC BY 4.0 (cropped)
- Medical devices that manipulate biological functions: “Bronze medical instruments, tweezers, another tools, Kanellopoulos Museum, 225058” Zde / CC BY-SA 4.0 (cropped)
- Related lab (Structural Analysis for Drug Discovery Lab): “Autism Aspect Pain Sensitivity 1” MissLunaRose12 / CC BY-SA 4.0 (cropped)
- Related lab (Pharmaceutics Lab): “Biological clock human-no” User:Soulkeeper / CC BY-SA 3.0 (cropped)
- Related lab (Green Pharma Structural Analysis Lab): “Protein Structure of human NDNF” Alpha Fold Team / CC BY 4.0 (cropped)
- Related lab (Molecular Pathology Analysis Lab): “Rust and dirt” Roger McLassus / CC BY-SA 3.0 (cropped)
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