Labs in Kyushu University, School of Medicine, Department of Medicine / Department of Life Sciences

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連携病態修復内科学講座 (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.

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A lab in gastroenterology and metabolism that studies whole-body metabolism starting from the gastrointestinal tract.

The Gastroenterology and Metabolism Lab studies the causes and pathophysiology of lifestyle-related diseases such as obesity and diabetes, focusing on connections between organs that start from the gastrointestinal tract. The background is the finding that the gastrointestinal tract senses stimuli such as nutrients and produces hormones such as incretins, and that, together with the gut microbiota, it takes part in whole-body nutrient metabolism. The lab combines basic research, multi-omics analysis (genome, epigenome, metabolome and others), and clinical research using the latest endoscopic equipment and endoscopic biopsy specimens, aiming to develop new diagnostic and treatment strategies. As an affiliated lab of the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, it also trains young researchers and physicians in the boundary area between gastroenterology and metabolism.

#Inter-organ crosstalk #Multi-omics analysis #Endoscopy

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A lab investigating the mechanisms by which body weight returns after weight loss in obesity.

Assistant Professor Yusuke Kajitani (Behavioral Metabolic Medicine Lab) studies the mechanisms of weight rebound, in which body weight increases again after it has been reduced through obesity treatment. The research theme is "Elucidating the mechanisms of post-weight-loss rebound through the hypothalamic glial network," which focuses on the relationship between changes in glial cells caused by the experience of obesity and the rebound phenomenon. Chronic inflammation in the hypothalamus is known to be involved in the progression of obesity, and inflammatory changes in microglia in particular may influence the regulation of eating behavior. The research uses mice in the "weight-loss rebound model" that Assistant Professor Kajitani established.

#Obesity #Weight regain after weight loss #Hypothalamic glia

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The lab explores new treatments for lung cancer through clinical trials and basic research.

At the Respiratory Medicine Clinical Collaboration Lab, Associate Professor Kentaro Tanaka studies the development of new treatments for lung cancer. The lab takes part in multicenter clinical trials and helps create new standard therapies for advanced-stage lung cancer. It also conducts molecular biological research on lung cancer, including immunological analyses to predict treatment efficacy and side effects. It also conducts research that brings findings originating in academia into actual clinical trials.

#Lung cancer #Immune checkpoint molecules #Clinical trials

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The lab explores the mechanisms and treatment of lung cancer and pulmonary fibrosis.

The Internal Medicine Division of the Research Institute for Diseases of the Chest studies respiratory diseases, including lung cancer. In lung cancer, the lab investigates how the disease develops at the molecular level, aiming to develop personalized treatments tailored to each patient. It also works on the mechanisms behind the onset of idiopathic pulmonary fibrosis and on developing treatments for lung cancer accompanied by interstitial pneumonia. For advanced non-small cell lung cancer, the lab has also worked on clinical trials comparing treatments that combine immunotherapy.

#Lung cancer #Idiopathic pulmonary fibrosis #Interstitial pneumonia

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An internal medicine lab that explores cardiovascular diseases such as heart failure and pulmonary hypertension through clinical practice and research.

Kyushu University's cardiovascular medicine lab provides clinical care for heart failure, arrhythmia, ischemic heart disease, pulmonary hypertension, and congenital heart disease, and also conducts basic and clinical research. Built on the foundation of the School of Medicine's Research Institute of Angiocardiology, it is made up of Cardiovascular Medicine in the Faculty of Medical Sciences and the Department of Cardiovascular Medicine at Kyushu University Hospital. Its research groups are divided into clinical research on heart failure, arrhythmia, and related conditions, and basic research on heart failure, blood vessels, pulmonary hypertension, and hypertension. The professor says the aim is to train physicians who combine advanced medical knowledge and skills with a mind for research.

#Heart failure #Pulmonary hypertension #Cardiology

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A lab that approaches heart and vascular diseases from the surgical side.

Professor Shiose of the Surgery Division, Cardiovascular Research Institute, works in cardiovascular surgery, and lists valvular heart disease, heart failure, and aortic disease among his research themes. In heart failure, the research themes include ventricular assist devices and heart transplantation. In valvular heart disease, the research themes include minimally invasive surgery (MICS) and da Vinci surgery. The Professor's profile also lists lung transplantation, artificial hearts, ischemic heart disease, and acute and chronic pulmonary thromboembolism as research themes.

#Valvular heart disease #Heart failure #Heart transplantation

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A lab that studies neuroimmune disorders and neuropathic pain from the perspective of neurology.

The Internal Medicine Division of the Brain and Neurological Diseases Research Institute is a lab that studies neurological diseases, mainly neuroimmune disorders. Professor Isobe works as a neurologist, seeing patients in outpatient clinics and on hospital wards, while also pursuing neuroimmunological research, clinical epidemiological research, and genetic research. Assistant Professor Fujii conducts research on neuropathic pain in neurology and supervises students in the doctoral program.

#Neuroimmunology #Neuromyelitis optica #Neuropathic pain

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A neurosurgery lab that investigates brain tumors and cerebrovascular disease.

The Surgery Division of the Brain and Neurological Diseases Research Institute conducts research in neurosurgery, mainly on brain tumors and cerebrovascular disease. The Professor works on molecular biological analysis of the pathology and treatment sensitivity of malignant brain tumors. The Associate Professor is involved in clinical work, research, and education in neurosurgery, and lists higher brain dysfunction in cerebrovascular disease and treatments for glioblastoma among the research themes.

#Glioblastoma #Cerebrovascular disease #Higher brain functions

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The lab explores how the shape of the body forms, using both mathematical modeling and experiments.

The lab studies how the shapes of living organisms take form, combining experiments in developmental biology with mathematical models from applied mathematics. It focuses in particular on "spontaneous pattern formation," in which shapes arise on their own from a state with no pre-existing structure, and investigates examples such as lung branching and the sutures of the skull. The lab belongs to the Faculty of Medical Sciences, and aims to connect the elucidation of the principles of shape formation to understanding the mechanisms of congenital anomalies and to building tissue structures in regenerative medicine. The lab's website presents it under the name "Systematic Anatomy."

#Spontaneous pattern formation #Developmental biology #Mathematical biology