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Research Institute for Diseases of the Chest, Internal Medicine Lab
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The lab explores the mechanisms and treatment of lung cancer and pulmonary fibrosis.
AboutAbout the lab
Uncovering how lung diseases arise, and linking it to treatment.
The Internal Medicine Division of the Research Institute for Diseases of the Chest studies respiratory diseases, including lung cancer.
In lung cancer, the lab investigates how the disease develops at the molecular level, aiming to develop personalized treatments tailored to each patient.
It also works on the mechanisms behind the onset of idiopathic pulmonary fibrosis and on developing treatments for lung cancer accompanied by interstitial pneumonia.
For advanced non-small cell lung cancer, the lab has also worked on clinical trials comparing treatments that combine immunotherapy.
Key terms
- Idiopathic pulmonary fibrosis
- A type of interstitial pneumonia in which lung tissue gradually becomes stiff, and whose cause is unclear
- Interstitial pneumonia
- A general term for diseases in which inflammation occurs in the interstitium, the part that forms the wall of the lungs
- Non-small cell lung cancer
- A collective term for the types of lung cancer other than small cell lung cancer
- Randomized controlled trial
- A trial that randomly assigns patients to treatment groups and compares the effects of the treatments
ResearchResearch themes
The lab investigates how respiratory diseases such as lung cancer and interstitial pneumonia develop, aiming to lead to new treatments. Research themes of the faculty include the molecular pathology of lung cancer, idiopathic pulmonary fibrosis, and clinical trials of immunotherapy.
*Illustrative imageMolecular pathology of lung cancer and personalized treatment
The lab aims to clarify the pathology of lung cancer at the molecular level and to develop strategies for personalized treatment.
*Illustrative imageMechanisms behind the onset of idiopathic pulmonary fibrosis
The lab analyzes the molecular mechanisms involved in the onset of idiopathic pulmonary fibrosis.
*Illustrative imageTreating lung cancer accompanied by interstitial pneumonia
The lab works on developing new treatments for patients with lung cancer who also have interstitial pneumonia.
*Illustrative imageClinical trials of immunotherapy for advanced lung cancer
The lab has worked on randomized controlled trials to establish the standard of care for treatments that combine immunotherapy for advanced non-small cell lung cancer.
MembersFaculty
- ProfessorIsamu Okamoto
- Associate ProfessorEiji Iwama
- LecturerKohei Otsubo
- Assistant ProfessorDaisuke Shibahara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Srifhistology3” Mutleysmith / CC BY-SA 4.0 (cropped)
- Molecular pathology of lung cancer and personalized treatment: “Personalized Medicine and Companion Diagnostics Go Hand-in-Hand” The U.S. Food and Drug Administration / Public domain (cropped)
- Mechanisms behind the onset of idiopathic pulmonary fibrosis: “Pulmon fibrosis” Drriad / CC BY-SA 3.0 (cropped)
- Treating lung cancer accompanied by interstitial pneumonia: “Desquamative interstitial pneumonia (DIP) 2” Yale Rosen / CC BY-SA 2.0 (cropped)
- Clinical trials of immunotherapy for advanced lung cancer: “Monoclonal antibodies used in the treatment of non small cell lung cancer and their mechanism of action” First line Immunotherapy for Non-Small Cell Lung Cancer. Nasser NJ, Gorenberg M, Agbarya A. Pharmaceuticals (Basel). 2020 Nov 8;13(11):373. doi: 10.3390/ph13110373. / CC BY 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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