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Center for Human Disease Models, Organ and Tissue Reconstruction Lab
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The lab explores how the shape of the body forms, using both mathematical modeling and experiments.
AboutAbout the lab
Decoding the principles of shape formation through mathematics and experiments
The lab studies how the shapes of living organisms take form, combining experiments in developmental biology with mathematical models from applied mathematics.
It focuses in particular on "spontaneous pattern formation," in which shapes arise on their own from a state with no pre-existing structure, and investigates examples such as lung branching and the sutures of the skull.
The lab belongs to the Faculty of Medical Sciences, and aims to connect the elucidation of the principles of shape formation to understanding the mechanisms of congenital anomalies and to building tissue structures in regenerative medicine.
The lab's website presents it under the name "Systematic Anatomy."
Key terms
- Spontaneous pattern formation
- A phenomenon in which periodic structures and other patterns arise on their own from a state that initially appears uniform
- Developmental biology
- The field that studies the process by which a single fertilized egg with no body shape becomes the shape of the body through cell division and differentiation
- Mathematical model
- A description of the mechanism of a phenomenon in mathematical equations, which is tested by comparing it with experimental results
NewsLab news
A paper on a 3D shaping method using shrinking sheets was published in Journal of the Royal Society Interface
A study on waves of spermatogenesis was published in Mathematical Biosciences
A study on human retinal vascular patterns was published in Translational Vision Science and Technology
A study on the shapes of keratitis lesions was published in Bulletin of Mathematical Biology
A study on peristaltic movement of the esophagus was published in Royal Society Open Science
ResearchResearch themes
The lab aims to elucidate the mechanisms by which the shape of the body forms. It combines experimental approaches such as molecular biology and experimental embryology, theoretical approaches such as applied mathematics and theoretical physics, and measurement approaches such as imaging and image processing.
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MembersFaculty
- ProfessorTakashi Miura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pattern formation 2” Jobsarayutw / CC BY-SA 4.0 (cropped)
- Exploring pattern formation in mammalian embryos through mathematics: “Reaction-difusion patterns” Gnomo4453 / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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