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Behavioral Metabolic Medicine Lab
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A lab investigating the mechanisms by which body weight returns after weight loss in obesity.
AboutAbout the lab
Exploring why weight comes back after weight loss.
Assistant Professor Yusuke Kajitani (Behavioral Metabolic Medicine Lab) studies the mechanisms of weight rebound, in which body weight increases again after it has been reduced through obesity treatment.
The research theme is "Elucidating the mechanisms of post-weight-loss rebound through the hypothalamic glial network," which focuses on the relationship between changes in glial cells caused by the experience of obesity and the rebound phenomenon.
Chronic inflammation in the hypothalamus is known to be involved in the progression of obesity, and inflammatory changes in microglia in particular may influence the regulation of eating behavior.
The research uses mice in the "weight-loss rebound model" that Assistant Professor Kajitani established.
Key terms
- Weight rebound
- The phenomenon in which body weight increases again after being reduced through obesity treatment.
- Microglia
- Cells involved in inflammation in the hypothalamus. The lab studies them because their inflammatory changes may influence the regulation of eating behavior.
- Single-cell analysis
- An analysis method that separates the cells of a tissue and examines them one by one.
ResearchResearch themes
The lab aims to clarify the molecular mechanisms of weight rebound, the return of body weight after obesity treatment. Using mice, it focuses on hypothalamic inflammation, especially changes in microglia.
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MembersFaculty
- Assistant ProfessorYusuke Kajitani
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bathroom Scale- )” Mason Masteka from Portland, ME, United States / CC BY-SA 2.0 (cropped)
- Mechanisms of rebound after weight loss: “Methodology of a study on diet induced obesity in mice” WolfLink / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
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