Labs in Tohoku University

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口腔免疫病態制御学講座（連携講座） (introduction coming soon)

Biological defense of the oral cavity as the front line against foreign substances and microorganisms; (1) host immune responses and defense mechanisms in oral mucosa; (2) autoantibody production mechanisms central to the pathogenesis of autoimmune diseases including Sjögren's syndrome; (3) regulation of cellular responses in tissue stem/progenitor cells; aiming at methods to control and repair oral diseases and strengthen biological defense

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長寿口腔科学講座（連携講座） (introduction coming soon)

Molecular and cellular biology of bone and joint diseases (including alveolar bone and temporomandibular joint) that reduce quality of life (QOL) in the elderly; basic and clinical research on dental caries and periodontal disease from vascular biology and bone metabolism perspectives

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A lab that searches for drug leads through the total synthesis of complex alkaloids and the development of new reactions.

The Pharmaceutical Manufacturing Chemistry Lab studies the synthesis of alkaloids that show biological activity important for medicine, and the development of new reactions for that purpose. Its targets are polycyclic alkaloids that are difficult to synthesize because of complex structures such as strained medium-sized rings. The lab aims to create new reactions that work even in the presence of various functional groups, and routes that synthesize complex compounds in few steps. Aiming to discover drug leads, the lab also works on developing enzyme inhibitors.

#Total synthesis #Alkaloids #Development of novel reactions

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An organic chemistry lab that designs molecules and creates new reactions.

The Molecular Design Chemistry Lab is a lab in the Graduate School of Pharmaceutical Sciences, Tohoku University, and studies, from the standpoint of organic chemistry, how to design molecules and create new reactions. It works on reactions using cobalt and palladium catalysts, and on reactions of small-ring molecules such as cyclopropanols. The lab believes that the appeal of organic chemistry lies in the process of envisioning the molecule one wants to make, building the reactions, and producing it as an actual substance. On the lab's website, it is introduced under the name "Yoshikai Group."

#Catalytic reactions #C–H bond activation #Axial chirality

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A lab that uses the power of organic synthesis to create bioactive molecules and pharmaceuticals.

The Synthetic Control Chemistry Lab conducts basic research that follows life phenomena from the standpoint of synthetic organic chemistry, with the aim of creating superior pharmaceuticals. Its central subject is the synthesis of biologically active compounds (mainly natural products). In addition, the lab develops catalytic reactions for efficiently making pharmaceuticals and other compounds, and creates molecular tools to study how drugs act. Research is carried out using not only experiments but also computational chemistry.

#Synthetic organic chemistry #Natural product synthesis #Catalytic reaction development

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The lab works on the total synthesis of natural organic compounds and the development of synthetic methods.

The Reaction Control Chemistry Lab (Doi Lab) studies the synthesis of organic compounds at the Faculty of Pharmaceutical Sciences and the Graduate School of Pharmaceutical Sciences, Tohoku University. The lab works on the total synthesis of biologically active natural organic compounds. It also develops efficient methods for preparing natural product derivatives, as well as methods for asymmetric synthesis. The lab also works on methods for constructing heterocycles and on the synthesis of molecular probes.

#Total synthesis #Asymmetric synthesis #Heterocycles

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The lab develops molecular transformation reactions of organic compounds using strong bases.

The Molecular Transformation Chemistry Lab works on developing diverse molecular transformation reactions of organic compounds. The lab develops molecular transformation reactions that use strong bases. The bases it handles include organic superbases, composite Brønsted bases, and highly active amide bases. The lab also works on the chemistry of boron- and nitrogen-containing heterocycles.

#Molecular transformation reactions #Strong bases #Organic superbases

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The lab searches for new natural products in the genomes of filamentous fungi.

The Medicinal Resources Chemistry Lab (Asai Lab) searches for new natural products from the blueprints of unknown compounds hidden in the genomes of filamentous fungi (molds). Secondary metabolites produced by filamentous fungi include many pharmacologically active substances, such as penicillin and lovastatin, and are recognized as a resource for exploring drug development. Using methods from organic chemistry, genetic engineering, and synthetic biology, the lab pursues "post-genomic natural product discovery" to obtain new secondary metabolites. The lab examines the pharmacological activity of the natural products it finds through collaborative research, aiming to use them in the search for substances that can serve as starting points for drugs.

#Genome mining #Natural product biosynthesis #Drug discovery seeds

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The lab explores the point of contact between living bodies and materials through polymer and interface science.

The Interfacial Physical Chemistry Lab studies biointerfaces, the surfaces where living bodies and materials come into contact, based on polymer chemistry and colloid and interface science. The lab focuses on biocompatible properties, creating interfaces and investigating their physical properties and functions in order to clarify how they interact with living bodies. The lab aims to turn the knowledge gained into technologies for manipulating molecules, and to return it to society as pharmaceuticals and medical devices. In graduate education, the lab aims to train people who have acquired not only knowledge of drug discovery but also the engineering research and development skills needed to create new things.

#Biointerfaces #Polymer biomaterials #Pharmaceutical formulation materials

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A molecular spectroscopy lab that uses light to investigate and control the structure and function of cells and molecules.

The Biological Structural Chemistry Lab investigates the structure and function of cells and biomolecules by molecular spectroscopy, a method of observing molecules using light. Using spectroscopic methods such as Raman scattering and fluorescence, the lab aims to understand at the molecular level how drugs and other agents work, and to lead to the development of new drugs and therapeutic technologies. The lab is also advancing applications to the treatment of diseases, such as using light to induce cell death in cancer cells and to suppress fibril formation of proteins. Although it is a biology lab, it is characterized by its use of the latest physical chemistry methods and theories, as well as statistical methods.

#Molecular spectroscopy #Raman imaging #In situ intracellular measurement