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Pharmaceutical Manufacturing Chemistry Lab
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A lab that searches for drug leads through the total synthesis of complex alkaloids and the development of new reactions.
AboutAbout the lab
Making complex compounds in just a few steps.
The Pharmaceutical Manufacturing Chemistry Lab studies the synthesis of alkaloids that show biological activity important for medicine, and the development of new reactions for that purpose.
Its targets are polycyclic alkaloids that are difficult to synthesize because of complex structures such as strained medium-sized rings.
The lab aims to create new reactions that work even in the presence of various functional groups, and routes that synthesize complex compounds in few steps.
Aiming to discover drug leads, the lab also works on developing enzyme inhibitors.
Key terms
- Alkaloid
- A general term for nitrogen-containing organic compounds produced by plants and other organisms. Many act as medicines or poisons.
- Total synthesis
- Artificially making a complex, naturally occurring compound from simple starting materials through a series of chemical reactions.
- Functional group
- A group of atoms within a molecule that determines its reactivity and properties.
NewsLab news
Assistant Professor Juri Sakata received the FY2026 Chemical Pharmaceutical Sciences Division Award of the Pharmaceutical Society of Japan
A master's student received an Excellent Presentation Award (Poster) at the 146th Annual Meeting of the Pharmaceutical Society of Japan
A paper on total synthesis was published in Angew. Chem. Int. Ed.
A master's student received an Excellent Oral Presentation Award at the 64th Tohoku Branch Meeting of the Pharmaceutical Society of Japan
A paper on the synthesis of indoles bearing a phosphate ester at the 2-position was published in Org. Lett.
ResearchResearch themes
The lab takes up alkaloids that show biological activity important for medicine but are difficult to synthesize because of their complex structures, and aims to develop new synthetic reactions and synthetic routes. It also pursues research aimed at discovering drug leads, such as the development of enzyme inhibitors.
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MembersFaculty
The members of the Pharmaceutical Manufacturing Chemistry Lab are faculty, technical assistants, students in the doctoral, master's, and undergraduate programs, and international students.As of 2026
- ProfessorHidetoshi Tokuyama
- Assistant ProfessorJuri Sakata
- Assistant ProfessorShuto Kosuge
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fume-hood” Giovanna Canu, Sofia Gambaro, Francesca Cirisano, CNR-ICMATE / CC BY 4.0 (cropped)
- Total Synthesis of Alkaloids and Development of New Reactions: “Organic Chemistry Lab 2 by marthou” Marthou / CC BY-SA 4.0 (cropped)
- Related lab (反応制御化学分野): “Round bottom flask 1” Stephanie cheks / CC BY-SA 4.0 (cropped)
- Related lab (医薬資源化学分野): “Aspergillus clavatus petri dish” Dr. Hilliard F. Hardin, CDC / Public domain (cropped)
- Related lab (分子変換化学分野): “8 Śląski Festiwal Nauki, MCK, Katowice,, , 1256” Krzysztof Popławski / CC BY-SA 4.0 (cropped)
- Related lab (合成制御化学分野): “Rotary evaporator” Y Chen / CC BY-SA 4.0 (cropped)
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