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28 labs · 0 student voices
Faculties at Tohoku University ›
Hidetoshi Tokuyama, Professor
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The Pharmaceutical Manufacturing Chemistry Lab studies the synthesis of alkaloids that show biological activity important for medicine, and the development of new reactions for that purpose. Its targets are polycyclic alkaloids that are difficult to synthesize because of complex structures such as strained medium-sized rings. The lab aims to create new reactions that work even in the presence of various functional groups, and routes that synthesize complex compounds in few steps. Aiming to discover drug leads, the lab also works on developing enzyme inhibitors.
Naohiko Yoshikai, Professor
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The Molecular Design Chemistry Lab is a lab in the Graduate School of Pharmaceutical Sciences, Tohoku University, and studies, from the standpoint of organic chemistry, how to design molecules and create new reactions. It works on reactions using cobalt and palladium catalysts, and on reactions of small-ring molecules such as cyclopropanols. The lab believes that the appeal of organic chemistry lies in the process of envisioning the molecule one wants to make, building the reactions, and producing it as an actual substance. On the lab's website, it is introduced under the name "Yoshikai Group."
Yoshiharu Iwabuchi, Professor
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The Synthetic Control Chemistry Lab conducts basic research that follows life phenomena from the standpoint of synthetic organic chemistry, with the aim of creating superior pharmaceuticals. Its central subject is the synthesis of biologically active compounds (mainly natural products). In addition, the lab develops catalytic reactions for efficiently making pharmaceuticals and other compounds, and creates molecular tools to study how drugs act. Research is carried out using not only experiments but also computational chemistry.
Takayuki Doi, Professor
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The Reaction Control Chemistry Lab (Doi Lab) studies the synthesis of organic compounds at the Faculty of Pharmaceutical Sciences and the Graduate School of Pharmaceutical Sciences, Tohoku University. The lab works on the total synthesis of biologically active natural organic compounds. It also develops efficient methods for preparing natural product derivatives, as well as methods for asymmetric synthesis. The lab also works on methods for constructing heterocycles and on the synthesis of molecular probes.
Masanori Shigeno, Professor
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The Molecular Transformation Chemistry Lab works on developing diverse molecular transformation reactions of organic compounds. The lab develops molecular transformation reactions that use strong bases. The bases it handles include organic superbases, composite Brønsted bases, and highly active amide bases. The lab also works on the chemistry of boron- and nitrogen-containing heterocycles.
Teigo Asai, Professor
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The Medicinal Resources Chemistry Lab (Asai Lab) searches for new natural products from the blueprints of unknown compounds hidden in the genomes of filamentous fungi (molds). Secondary metabolites produced by filamentous fungi include many pharmacologically active substances, such as penicillin and lovastatin, and are recognized as a resource for exploring drug development. Using methods from organic chemistry, genetic engineering, and synthetic biology, the lab pursues "post-genomic natural product discovery" to obtain new secondary metabolites. The lab examines the pharmacological activity of the natural products it finds through collaborative research, aiming to use them in the search for substances that can serve as starting points for drugs.
Tomohiro Konno, Professor
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The Interfacial Physical Chemistry Lab studies biointerfaces, the surfaces where living bodies and materials come into contact, based on polymer chemistry and colloid and interface science. The lab focuses on biocompatible properties, creating interfaces and investigating their physical properties and functions in order to clarify how they interact with living bodies. The lab aims to turn the knowledge gained into technologies for manipulating molecules, and to return it to society as pharmaceuticals and medical devices. In graduate education, the lab aims to train people who have acquired not only knowledge of drug discovery but also the engineering research and development skills needed to create new things.
Takakazu Nakabayashi, Professor
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The Biological Structural Chemistry Lab investigates the structure and function of cells and biomolecules by molecular spectroscopy, a method of observing molecules using light. Using spectroscopic methods such as Raman scattering and fluorescence, the lab aims to understand at the molecular level how drugs and other agents work, and to lead to the development of new drugs and therapeutic technologies. The lab is also advancing applications to the treatment of diseases, such as using light to induce cell death in cancer cells and to suppress fibril formation of proteins. Although it is a biology lab, it is characterized by its use of the latest physical chemistry methods and theories, as well as statistical methods.
Shozo Furumoto, Professor
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The Molecular Kinetics Analysis Lab, as the Nuclear Pharmacy Division of the Center for Advanced Quantum Beam Science, studies the use in the life sciences of radionuclides produced by a cyclotron. The lab aims to use PET imaging, which employs short-lived positron-emitting nuclides, in medical diagnosis and drug discovery research. Based on basic research on the design and synthesis of labeled compounds, the lab works on developing new diagnostic probes for PET and evaluating them with small-animal PET. As a cooperating division of the Department of Pharmaceutical Life Sciences in the Graduate School of Pharmaceutical Sciences, the lab accepts undergraduate and graduate students in pharmacy.
Ming-Rong Zhang, Visiting Professor
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The Molecular Imaging Pharmaceutical Sciences Lab is part of the Collaborative Department of Molecular Imaging Pharmaceutical Sciences in the Graduate School of Pharmaceutical Sciences, and works in partnership with the National Institute of Radiological Sciences at the National Institutes for Quantum Science and Technology (QST). The research topics listed for the lab include the drug-discovery-oriented development of radiopharmaceuticals and exploratory research. The targets are agents aimed at detecting the function of the brain defense system, agents that capture intracellular signal transduction, and agents used to evaluate tumor malignancy and drug sensitivity. The department's page lists Visiting Professor Ming-Rong Zhang as a faculty and staff member.
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