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Interfacial Physical Chemistry Lab
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The lab explores the point of contact between living bodies and materials through polymer and interface science.
AboutAbout the lab
Opening up new medicine from the interface with living bodies.
The Interfacial Physical Chemistry Lab studies biointerfaces, the surfaces where living bodies and materials come into contact, based on polymer chemistry and colloid and interface science.
The lab focuses on biocompatible properties, creating interfaces and investigating their physical properties and functions in order to clarify how they interact with living bodies.
The lab aims to turn the knowledge gained into technologies for manipulating molecules, and to return it to society as pharmaceuticals and medical devices.
In graduate education, the lab aims to train people who have acquired not only knowledge of drug discovery but also the engineering research and development skills needed to create new things.
Key terms
- Biointerface
- The interface where living bodies come into contact with materials, pharmaceuticals, medical devices, and the like. The biological and cellular responses that occur here are studied.
- Colloid and interface science
- The academic field that deals with the state in which minute particles are dispersed in a liquid, and with the properties of the surfaces where substances meet.
- Solubilization
- Making a substance that is poorly soluble in water usable in a state dissolved in water.
- Hydrogel
- A soft, gel-like material that contains a large amount of water.
NewsLab news
An undergraduate student received the Dean of the Faculty of Pharmaceutical Sciences Award for fiscal 2023
Assistant Professor Yuta Nozaki received the 2023 Award for Encouragement of Research in Polymer Science from the Society of Polymer Science, Japan
ResearchResearch themes
The lab studies a variety of interfaces: between living bodies and biomaterials, between biomaterials and pharmaceuticals or medical devices, and between pharmaceuticals or medical devices and living bodies. Based on polymer chemistry and colloid and interface science, the lab creates biointerfaces and clarifies the biological and cellular responses that occur there, aiming to generate knowledge and technologies that lead to new pharmaceuticals and medical devices.
*Illustrative imageBiomaterials as formulation materials
With the biomaterials that have been used as formulation materials, the cellular responses that begin with the adsorption and denaturation of biomolecules cannot be controlled. The lab creates new polymer biomaterials with clearly defined chemical structures and works to elucidate biological and cellular responses that have not been found so far.
*Illustrative imageFunctions as formulation materials and formulation technology
The lab studies formulation technologies for using drug candidate compounds that are poorly soluble in water or unstable safely and effectively. It develops fundamental technologies such as solubilization with molecular assemblies of biocompatible polymers, nanoparticle formation, and hydrogel formation, and also works on new drug delivery technologies that take the route of administration and the site of application into account.
*Illustrative imageDrug discovery engineering using cells
The lab aims to derive molecular-scientific and physicochemical parameters that regulate how the functions of cells and their tissue constructs appear. It develops nonclinical testing methods for formulation materials such as nanoparticles, and focuses on deriving the parameters needed to deliver drugs deep into the extracellular matrix.
MembersFaculty
The members of the Interfacial Physical Chemistry Lab consist of faculty and master's and undergraduate students.As of 2024
- ProfessorTomohiro Konno
- Assistant ProfessorYuta Nozaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Advanced Measurement Laboratory; Sample Prep, Chemical Micro and Nanoanalysis ( )” National Institute of Standards and Technology / Public domain (cropped)
- Biomaterials as formulation materials: “ProteinAdsorptionPrevention” RabidRabbit23 (Andrew White) / CC BY 3.0 (cropped)
- Functions as formulation materials and formulation technology: “Mucosta (rebamipide) 100 mg tablets, Otsuka Pharmaceutical” 倶楽部オータム / CC BY-SA 3.0 (cropped)
- Drug discovery engineering using cells: “HaCaT Cells Phase Contrast” Accuratelibrarian / CC BY-SA 4.0 (cropped)
- Related lab (病態分子薬学分野): “Ion chromatograph in combination with a mass spectrometer, in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Related lab (環境調和化学分野): “BuretteFumeHood” Walkerma / CC BY-SA 3.0 (cropped)
- Related lab (分子設計化学分野): “Vintage laboratory glassware” LukaszKatlewa / CC BY 4.0 (cropped)
- Related lab (分子細胞生化学分野): “NEUROTENSIN RECEPTOR 2” rcsb pdb / CC BY 4.0 (cropped)
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